Link to the University of Pittsburgh Homepage
Link to the University Library System Homepage Link to the Contact Us Form

Effects of weight loss and insulin reduction on arterial stiffness in the SAVE trial

Hughes, TM and Althouse, AD and Niemczyk, NA and Hawkins, MS and Kuipers, AL and Sutton-Tyrrell, K (2012) Effects of weight loss and insulin reduction on arterial stiffness in the SAVE trial. Cardiovascular Diabetology, 11.

[img]
Preview
PDF
Published Version
Available under License : See the attached license file.

Download (207kB) | Preview
[img] Plain Text (licence)
Available under License : See the attached license file.

Download (1kB)

Abstract

Background: Chronic arterial stiffness contributes to the negative health effects of obesity and insulin resistance, which include hypertension, stroke, and increased cardiovascular and all-cause mortality. Weight loss and improved insulin sensitivity are individually associated with improved central arterial stiffness; however, their combined effects on arterial stiffness are poorly understood. The purpose of this study was to determine how insulin levels modify the improvements in arterial stiffness seen with weight loss in overweight and obese young adults.Methods: To assess the effects of weight loss and decreased fasting insulin on vascular stiffness, we studied 339 participants in the Slow the Adverse Effects of Vascular Aging (SAVE) trial. At study entry, the participants were aged 20-45, normotensive, non-diabetic, and had a body-mass index of 25-39.9 kg/m 2 . Measures of pulse wave velocity (PWV) in the central (carotid-femoral (cfPWV)), peripheral (femoral-ankle (faPWV)), and mixed (brachial-ankle (baPWV)) vascular beds were collected at baseline and 6 months. The effects of 6-month change in weight and insulin on measures of PWV were estimated using multivariate regression.Results: After adjustment for baseline risk factors and change in systolic blood pressure, 6-month weight loss and 6-month change in fasting insulin independently predicted improvement in baPWV but not faPWV or cfPWV. There was a significant interaction between 6-month weight change and change in fasting insulin when predicting changes in baPWV (p < 0.001). Individuals experiencing both weight loss and insulin reductions showed the greatest improvement in baPWV.Conclusions: Young adults with excess weight who both lower their insulin levels and lose weight see the greatest improvement in vascular stiffness. This improvement in vascular stiffness with weight loss and insulin declines may occur throughout the vasculature and may not be limited to individual vascular beds.Trial registration: NCT00366990. © 2012 Hughes et al.; licensee BioMed Central Ltd.


Share

Citation/Export:
Social Networking:
Share |

Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Hughes, TM
Althouse, AD
Niemczyk, NAnan37@pitt.eduNAN37
Hawkins, MS
Kuipers, ALkuipersa@edc.pitt.eduKUIPERS
Sutton-Tyrrell, K
Date: 22 September 2012
Date Type: Publication
Journal or Publication Title: Cardiovascular Diabetology
Volume: 11
DOI or Unique Handle: 10.1186/1475-2840-11-114
Schools and Programs: Graduate School of Public Health > Epidemiology
Refereed: Yes
Date Deposited: 11 Oct 2016 18:27
Last Modified: 27 Apr 2019 12:55
URI: http://d-scholarship.pitt.edu/id/eprint/29829

Metrics

Monthly Views for the past 3 years

Plum Analytics

Altmetric.com


Actions (login required)

View Item View Item