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Bench to bedside review: Extracorporeal carbon dioxide removal, past present and future

Cove, ME and MacLaren, G and Federspiel, WJ and Kellum, JA (2012) Bench to bedside review: Extracorporeal carbon dioxide removal, past present and future. Critical Care, 16 (5). ISSN 1364-8535

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Acute respiratory distress syndrome (ARDS) has a substantial mortality rate and annually affects more than 140,000 people in the USA alone. Standard management includes lung protective ventilation but this impairs carbon dioxide clearance and may lead to right heart dysfunction or increased intracranial pressure. Extracorporeal carbon dioxide removal has the potential to optimize lung protective ventilation by uncoupling oxygenation and carbon dioxide clearance. The aim of this article is to review the carbon dioxide removal strategies that are likely to be widely available in the near future. Relevant published literature was identified using PubMed and Medline searches. Queries were performed by using the search terms ECCOR, AVCO2R, VVCO2R, respiratory dialysis, and by combining carbon dioxide removal and ARDS. The only search limitation imposed was English language. Additional articles were identified from reference lists in the studies that were reviewed. Several novel strategies to achieve carbon dioxide removal were identified, some of which are already commercially available whereas others are in advanced stages of development. © 2012 BioMed Central Ltd.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Cove, ME
MacLaren, G
Federspiel, WJfederspielwj@pitt.eduWFEDERSP0000-0002-7068-6779
Kellum, JAkellum@pitt.eduKELLUM0000-0003-1995-2653
Centers: Other Centers, Institutes, Offices, or Units > McGowan Institute for Regenerative Medicine
Date: 21 September 2012
Date Type: Publication
Journal or Publication Title: Critical Care
Volume: 16
Number: 5
DOI or Unique Handle: 10.1186/cc11356
Schools and Programs: School of Medicine > Critical Care Medicine
Swanson School of Engineering > Bioengineering
Swanson School of Engineering > Chemical Engineering
Refereed: Yes
ISSN: 1364-8535
Article Type: Review
Date Deposited: 11 Oct 2016 18:26
Last Modified: 30 Oct 2018 13:55


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