DNA damage as a result of psychological stress: implications for breast cancer

Flint, MS and Bovbjerg, DH (2012) DNA damage as a result of psychological stress: implications for breast cancer. Breast Cancer Research, 14 (5). ISSN 1465-5411

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Abstract

Accumulating evidence indicates that psychological stress can have deleterious influences on cancer development and progression, but the mechanisms responsible remain unclear. One possible mechanism is suggested by emerging evidence that DNA damage is increased by exposure to stress and stress hormones (for example, cortisol, catecholamines). Possible molecular mechanisms for such effects were the subject of a recent paper by Hara and colleagues, which suggests that chronic stress, through β-adrenergic stimulation, can induce two synergistic pathways that result in accumulation of DNA damage. Herein, we discuss the potential implications of these findings for breast cancer etiology, progression, and treatment response. © 2012 BioMed Central Ltd.

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Details

Item Type:	Article
Status:	Published
Creators/Authors:	Creators Email Pitt Username ORCID Flint, MS msf10@pitt.edu MSF10 Bovbjerg, DH dhb15@pitt.edu DHB15
Centers:	Other Centers, Institutes, Offices, or Units > Pittsburgh Cancer Institute
Date:	21 September 2012
Date Type:	Publication
Journal or Publication Title:	Breast Cancer Research
Volume:	14
Number:	5
DOI or Unique Handle:	10.1186/bcr3189
Schools and Programs:	Dietrich School of Arts and Sciences > Psychology School of Public Health > Behavioral and Community Health Sciences School of Medicine > Pharmacology and Chemical Biology School of Medicine > Psychiatry
Refereed:	Yes
ISSN:	1465-5411
Date Deposited:	11 Oct 2016 18:26
Last Modified:	04 Feb 2019 15:56
URI:	http://d-scholarship.pitt.edu/id/eprint/29831

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