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Zoledronic acid effectiveness against breast cancer metastases - a role for estrogen in the microenvironment?

Steinman, RA and Brufsky, AM and Oesterreich, S (2012) Zoledronic acid effectiveness against breast cancer metastases - a role for estrogen in the microenvironment? Breast Cancer Research, 14 (5). ISSN 1465-5411

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Abstract

Zoledronic acid (ZA) is an imidazole-containing bisphosphonate that has been extensively studied as an osteoclast inhibitor. ZA decreases bone turnover and has been effective in limiting osteolysis in metastatic cancers, including breast cancer. Recent clinical trials that demonstrated enhancement of disease-free survival by bisphosphonates have prompted interest in bisphosphonates as anti-cancer agents. ZA, for example, increased disease-free survival in postmenopausal and in premenopausal, hormone-suppressed breast cancer patients. Intriguingly, however, there was a lack of an anti-cancer effect of ZA in premenopausal women without ovarian suppression. These observations have prompted the conjecture that anti-cancer effects of ZA are limited to estrogen-poor environments. This review explores possible mechanisms compatible with differences in ZA activity in premenopausal women compared with postmenopausal (or hormone-suppressed) women. © 2012 BioMed Central Ltd.


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Steinman, RAsteinman@pitt.eduSTEINMAN
Brufsky, AMadb5@pitt.eduADB5
Oesterreich, Ssto16@pitt.eduSTO16
Centers: Other Centers, Institutes, or Units > Hillman Cancer Center
Other Centers, Institutes, or Units > Magee-Women's Research Institute
Other Centers, Institutes, or Units > Pittsburgh Cancer Institute
Date: 21 September 2012
Date Type: Publication
Journal or Publication Title: Breast Cancer Research
Volume: 14
Number: 5
DOI or Unique Handle: 10.1186/bcr3223
Schools and Programs: School of Medicine > Medicine
School of Medicine > Pharmacology and Chemical Biology
Refereed: Yes
ISSN: 1465-5411
Article Type: Review
Date Deposited: 11 Oct 2016 18:25
Last Modified: 04 Feb 2019 15:58
URI: http://d-scholarship.pitt.edu/id/eprint/29833

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