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Clinical review: Serious adverse events associated with the use of rituximab - a critical care perspective

Kasi, PM and Tawbi, HA and Oddis, CV and Kulkarni, HS (2012) Clinical review: Serious adverse events associated with the use of rituximab - a critical care perspective. Critical Care, 16 (4). ISSN 1364-8535

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Abstract

The advent of biologic agents has provided a more specific and targeted approach to the treatment of various hematological malignancies and other autoimmune disorders. Such biologic agents have been relatively well tolerated with fewer adverse events reported as compared with many other chemotherapeutic agents. Rituximab is a monoclonal antibody to the B-cell marker CD20 and is a common biologic agent widely used for the treatment of B-cell lymphoma, lymphoproliferative disorders, and inflammatory conditions that are refractory to conventional treatment, including rheumatoid arthritis and some vasculitides. However, through randomized controlled trials and post-marketing surveillance, an increasing number of serious adverse events are being associated with the use of rituximab, often leading to or complicating an intensive care unit admission. The purpose of this review is to focus on the severe complications that are associated with the use of rituximab and that require critical care. Management and prevention strategies for the most common complications along with some examples of its uses within the critical care setting are also discussed. © 2012 BioMed Central Ltd.


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Kasi, PM
Tawbi, HAhat9@pitt.eduHAT9
Oddis, CVcvo5@pitt.eduCVO5
Kulkarni, HS
Centers: Other Centers, Institutes, or Units > Arthritis Institute
Date: 31 August 2012
Date Type: Publication
Journal or Publication Title: Critical Care
Volume: 16
Number: 4
DOI or Unique Handle: 10.1186/cc11304
Schools and Programs: School of Medicine > Immunology
School of Medicine > Medicine
Refereed: Yes
ISSN: 1364-8535
Article Type: Review
Date Deposited: 29 Nov 2016 21:06
Last Modified: 02 Feb 2019 13:58
URI: http://d-scholarship.pitt.edu/id/eprint/29843

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