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PDLIM2 restricts Th1 and Th17 differentiation and prevents autoimmune disease

Qu, Z and Fu, J and Ma, H and Zhou, J and Jin, M and Mapara, MY and Grusby, MJ and Xiao, G (2012) PDLIM2 restricts Th1 and Th17 differentiation and prevents autoimmune disease. Cell and Bioscience, 2 (1).

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Abstract

Background: PDLIM2 is essential for the termination of the inflammatory transcription factors NF-κB and STAT but is dispensable for the development of immune cells and immune tissues/organs. Currently, it remains unknown whether and how PDLIM2 is involved in physiologic and pathogenic processes. Results: Here we report that naive PDLIM2 deficient CD4 + T cells were prone to differentiate into Th1 and Th17 cells. PDLIM2 deficiency, however, had no obvious effect on lineage commitment towards Th2 or Treg cells. Notably, PDLIM2 deficient mice exhibited increased susceptibility to experimental autoimmune encephalitis (EAE), a Th1 and/or Th17 cell-mediated inflammatory disease model of multiple sclerosis (MS). Mechanistic studies further indicate that PDLIM2 was required for restricting expression of Th1 and Th17 cytokines, which was in accordance with the role of PDLIM2 in the termination of NF-κB and STAT activation.Conclusion: These findings suggest that PDLIM2 is a key modulator of T-cell-mediated immune responses that may be targeted for the therapy of human autoimmune diseases. © 2012 Qu et al.; licensee BioMed Central Ltd.


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Qu, Zzhq4@pitt.eduZHQ4
Fu, J
Ma, H
Zhou, Jjiz76@pitt.eduJIZ76
Jin, M
Mapara, MY
Grusby, MJ
Xiao, Ggux8@pitt.eduGUX8
Centers: Other Centers, Institutes, or Units > Pittsburgh Cancer Institute
Date: 25 June 2012
Date Type: Publication
Journal or Publication Title: Cell and Bioscience
Volume: 2
Number: 1
DOI or Unique Handle: 10.1186/2045-3701-2-23
Schools and Programs: School of Medicine > Immunology
School of Medicine > Infectious Diseases and Microbiology
School of Medicine > Medicine
School of Medicine > Microbiology and Molecular Genetics
Refereed: Yes
Date Deposited: 29 Nov 2016 21:00
Last Modified: 12 Mar 2019 15:55
URI: http://d-scholarship.pitt.edu/id/eprint/29872

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