Link to the University of Pittsburgh Homepage
Link to the University Library System Homepage Link to the Contact Us Form

Subclinical AKI is still AKI

Ronco, C and Kellum, JA and Haase, M (2012) Subclinical AKI is still AKI. Critical Care, 16 (3). ISSN 1364-8535

Published Version
Available under License : See the attached license file.

Download (197kB) | Preview
[img] Plain Text (licence)
Available under License : See the attached license file.

Download (1kB)


The concept of acute kidney syndromes has shifted in recent years from acute renal failure to acute kidney injury (AKI). AKI implies injury or damage but not necessarily dysfunction. The human kidney has an important glomerular function reserve, and dysfunction becomes evident only when more than 50% of the renal mass is compromised. Recent AKI classifications include even slight changes in serum creatinine, acknowledging that this condition is associated with worse outcomes. This, however, still represents a functional criterion for AKI and implies a glomerular filtration rate alteration that may be a late phenomenon in the time course of the syndrome. An early diagnosis of AKI by using tubular damage biomarkers preceding filtration function loss is possible today. Some studies have shown evidence that there is an additional value of new biomarkers not only because they allow a diagnosis to be made earlier but also because they allow a kidney injury to be diagnosed even in the absence of subsequent dysfunction. Only recently, tubular damage without glomerular function loss was demonstrated to be associated with worse renal and overall outcomes. For this condition, the term 'subclinical' AKI has been introduced, challenging the traditional view that a kidney problem is clinically relevant, only when a loss of filtration function becomes apparent. A new domain of AKI diagnosis could then include functional criteria and damage criteria. This may have an impact on the epidemiology, prevention, and management of AKI. © 2012 BioMed Central Ltd.


Social Networking:
Share |


Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Ronco, C
Kellum, JAkellum@pitt.eduKELLUM0000-0003-1995-2653
Haase, M
Date: 21 June 2012
Date Type: Publication
Journal or Publication Title: Critical Care
Volume: 16
Number: 3
DOI or Unique Handle: 10.1186/cc11240
Schools and Programs: School of Medicine > Critical Care Medicine
Refereed: Yes
ISSN: 1364-8535
Date Deposited: 14 Oct 2016 15:42
Last Modified: 16 Sep 2019 13:55


Monthly Views for the past 3 years

Plum Analytics

Actions (login required)

View Item View Item