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To bind or not to bind - FoxA1 determines estrogen receptor action in breast cancer progression

Watters, RJ and Benos, PV and Oesterreich, S (2012) To bind or not to bind - FoxA1 determines estrogen receptor action in breast cancer progression. Breast Cancer Research, 14 (3). ISSN 1465-5411

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Abstract

Chromatin immunoprecipitation followed by massively parallel sequencing (ChIP-seq) is rapidly enabling the comprehensive characterization of genome-wide transcription factor-binding sites, thus defining the cistrome (cis-acting DNA targets of a trans-acting factor). Estrogen receptor (ER) ChIP-seq studies have been performed mainly in cell lines, but Ross-Innes and colleagues have now completed the first such study in clinical breast cancer samples. The study aimed at determining the dynamics of ER binding and differences between more and less aggressive primary breast tumors and metastases. The authors found that ER bound to DNA in both aggressive and drug-resistant tumors but to different sites and with different affinities. Given previous findings from cell lines, FoxA1 appears to play a critical role in this reprogramming of ER binding. © 2012 BioMed Central Ltd.


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Watters, RJrjw63@pitt.eduRJW63
Benos, PVbenos@pitt.eduBENOS
Oesterreich, Ssto16@pitt.eduSTO16
Centers: Other Centers, Institutes, or Units > Magee-Women's Research Institute
Other Centers, Institutes, or Units > Pittsburgh Cancer Institute
Date: 19 June 2012
Date Type: Publication
Journal or Publication Title: Breast Cancer Research
Volume: 14
Number: 3
DOI or Unique Handle: 10.1186/bcr3146
Refereed: Yes
ISSN: 1465-5411
Date Deposited: 14 Oct 2016 15:42
Last Modified: 05 Feb 2019 03:55
URI: http://d-scholarship.pitt.edu/id/eprint/29876

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