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Early diagnosis to enable early treatment of pre-osteoarthritis

Chu, CR and Williams, AA and Coyle, CH and Bowers, ME (2012) Early diagnosis to enable early treatment of pre-osteoarthritis. Arthritis Research and Therapy, 14 (3). ISSN 1478-6354

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Abstract

Osteoarthritis is a prevalent and disabling disease affecting an increasingly large swathe of the world population. While clinical osteoarthritis is a late-stage condition for which disease-modifying opportunities are limited, osteoarthritis typically develops over decades, offering a long window of time to potentially alter its course. The etiology of osteoarthritis is multifactorial, showing strong associations with highly modifiable risk factors of mechanical overload, obesity and joint injury. As such, characterization of pre-osteoarthritic disease states will be critical to support a paradigm shift from palliation of late disease towards prevention, through early diagnosis and early treatment of joint injury and degeneration to reduce osteoarthritis risk. Joint trauma accelerates development of osteoarthritis from a known point in time. Human joint injury cohorts therefore provide a unique opportunity for evaluation of pre-osteoarthritic conditions and potential interventions from the earliest stages of degeneration. This review focuses on recent advances in imaging and biochemical biomarkers suitable for characterization of the pre-osteoarthritic joint as well as implications for development of effective early treatment strategies. © 2012 BioMed Central Ltd.

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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Chu, CR
Williams, AA
Coyle, CH
Bowers, ME
Date: 7 June 2012
Date Type: Publication
Journal or Publication Title: Arthritis Research and Therapy
Volume: 14
Number: 3
DOI or Unique Handle: 10.1186/ar3845
Schools and Programs: School of Medicine > Orthopaedic Surgery
Refereed: Yes
ISSN: 1478-6354
Article Type: Review
Date Deposited: 14 Oct 2016 17:23
Last Modified: 29 Jan 2019 15:55
URI: http://d-scholarship.pitt.edu/id/eprint/29884

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