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Workshop on immunotherapy combinations. Society for immunotherapy of cancer annual meeting Bethesda, November 3, 2011

Forero, Ivan Martinez and Okada, Hideho and Topalian, Suzanne L and Gajewski, Thomas F and Korman, Alan J and Melero, Ignacio (2012) Workshop on immunotherapy combinations. Society for immunotherapy of cancer annual meeting Bethesda, November 3, 2011. Journal of Translational Medicine, 10 (1).

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Abstract

<jats:title>Abstract</jats:title> <jats:p>Although recent FDA approvals on ipilimumab and sipuleucel-T represent major milestones, the ultimate success of immunotherapy approaches will likely benefit from appropriate combinations with other immunotherapeutic and/or non-immunotherapeutic approaches. However, implementation of ideal combinations in the clinic may still face formidable challenges in regulatory, drug-availability and intellectual property aspects. The 2011 SITC annual meeting hosted a workshop on combination immunotherapy to discuss: 1) the most promising combinations found in the laboratory; 2) early success of combination immunotherapy in clinical trials; 3) industry perspectives on combination approaches, and 4) relevant regulatory issues. The integrated theme was how to accelerate the implementation of efficacious combined immunotherapies for cancer patients. Rodent animal models are providing many examples of synergistic combinations that typically include more than two agents. However, mouse and human immunology differ in a significant number of mechanisms and hence we might be missing opportunities peculiar to humans. Nonetheless, incisive animal experimentation with deep mechanistic insight remains the best compass that we can use to guide our paths in combinatorial immunotherapy. Combination immunotherapy clinical trials are already in progress and preliminary results are extremely promising. As a key to translate promising combinations into clinic, real and “perceived” business and regulatory hurdles were debated. A formidable step forward would be to be able to test combinations of investigational agents prior to individual approval. Taking together the FDA and the industrial perspective on combinatorial immunotherapy, the audience was left with the clear message that this is by no means an impossible task. The general perception is that the road ahead of us is full of combination clinical trials which hopefully will bring clinical benefit to our cancer patients at a fast pace.</jats:p>

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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Forero, Ivan Martinez
Okada, Hidehookada@pitt.eduOKADA
Topalian, Suzanne L
Gajewski, Thomas F
Korman, Alan J
Melero, Ignacio
Date: December 2012
Date Type: Publication
Journal or Publication Title: Journal of Translational Medicine
Volume: 10
Number: 1
Publisher: Springer Science and Business Media LLC
DOI or Unique Handle: 10.1186/1479-5876-10-108
Schools and Programs: School of Medicine > Neurological Surgery
Refereed: Yes
Date Deposited: 14 Oct 2016 15:26
Last Modified: 05 Sep 2021 14:55
URI: http://d-scholarship.pitt.edu/id/eprint/29888

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