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Adjuvant treatment of HER2-positive breast cancer: Winning efforts continue to improve HER2-positive patient outcome long-term

Jankowitz, RC and Brufsky, AM (2012) Adjuvant treatment of HER2-positive breast cancer: Winning efforts continue to improve HER2-positive patient outcome long-term. Breast Cancer Research, 14 (2). ISSN 1465-5411

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Abstract

Randomized adjuvant trials continue to show significant reductions in distant recurrence and death for early-stage women treated with adjuvant trastuzumab. BCIRG-006 showed superior disease-free and overall survival of two trastuzumab-containing regimens in comparison to a non-trastuzumab-containing regimen. The rates of disease-free and overall survival were not statistically different for the two trastuzumab-containing arms. Ongoing study is needed to identify markers of resistance to trastuzumab and incorporate newer agents in the adjuvant setting in order to further decrease rates of distant recurrence and death from HER2-positive breast cancer. © 2012 BioMed Central Ltd.


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Jankowitz, RCrcj8@pitt.eduRCJ8
Brufsky, AMadb5@pitt.eduADB5
Centers: Other Centers, Institutes, or Units > Magee-Women's Research Institute
Other Centers, Institutes, or Units > Pittsburgh Cancer Institute
Date: 30 April 2012
Date Type: Publication
Journal or Publication Title: Breast Cancer Research
Volume: 14
Number: 2
DOI or Unique Handle: 10.1186/bcr3120
Refereed: Yes
ISSN: 1465-5411
Date Deposited: 01 Nov 2016 18:36
Last Modified: 04 Feb 2019 16:55
URI: http://d-scholarship.pitt.edu/id/eprint/29915

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