Link to the University of Pittsburgh Homepage
Link to the University Library System Homepage Link to the Contact Us Form

Gastrin-releasing peptide receptor expression in non-cancerous bronchial epithelia is associated with lung cancer: A case-control study

UNSPECIFIED (2012) Gastrin-releasing peptide receptor expression in non-cancerous bronchial epithelia is associated with lung cancer: A case-control study. Respiratory Research, 13. ISSN 1465-9921

[img]
Preview
PDF
Published Version
Available under License : See the attached license file.

Download (433kB) | Preview
[img] Plain Text (licence)
Available under License : See the attached license file.

Download (1kB)

Abstract

Background: Normal bronchial tissue expression of GRPR, which encodes the gastrin-releasing peptide receptor, has been previously reported by us to be associated with lung cancer risk in 78 subjects, especially in females. We sought to define the contribution of GRPR expression in bronchial epithelia to lung cancer risk in a larger case-control study where adjustments could be made for tobacco exposure and sex.Methods: We evaluated GRPR mRNA levels in histologically normal bronchial epithelial cells from 224 lung cancer patients and 107 surgical cancer-free controls. Associations with lung cancer were tested using logistic regression models.Results: Bronchial GRPR expression was significantly associated with lung cancer (OR = 4.76; 95% CI = 2.32-9.77) in a multivariable logistic regression (MLR) model adjusted for age, sex, smoking status and pulmonary function. MLR analysis stratified by smoking status indicated that ORs were higher in never and former smokers (OR = 7.74; 95% CI = 2.96-20.25) compared to active smokers (OR = 1.69; 95% CI = 0.46-6.33). GRPR expression did not differ by subject sex, and lung cancer risk associated with GRPR expression was not modified by sex.Conclusions: GRPR expression in non-cancerous bronchial epithelium was significantly associated with the presence of lung cancer in never and former smokers. The association in never and former smokers was found in males and females. Association with lung cancer did not differ by sex in any smoking group. © 2012 Egloff et al; licensee BioMed Central Ltd.


Share

Citation/Export:
Social Networking:
Share |

Details

Item Type: Article
Status: Published
Date: 1 February 2012
Date Type: Publication
Journal or Publication Title: Respiratory Research
Volume: 13
DOI or Unique Handle: 10.1186/1465-9921-13-9
Schools and Programs: Graduate School of Public Health > Biostatistics
School of Medicine > Medicine
School of Medicine > Otolaryngology
School of Medicine > Pharmacology and Chemical Biology
School of Medicine > Surgery
Refereed: Yes
ISSN: 1465-9921
Date Deposited: 01 Nov 2016 18:19
Last Modified: 05 Jan 2019 16:56
URI: http://d-scholarship.pitt.edu/id/eprint/29962

Metrics

Monthly Views for the past 3 years

Plum Analytics

Altmetric.com


Actions (login required)

View Item View Item