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Clinical practice of image-guided spine radiosurgery - results from an international research consortium

Guckenberger, M and Sweeney, RA and Flickinger, JC and Gerszten, PC and Kersh, R and Sheehan, J and Sahgal, A (2011) Clinical practice of image-guided spine radiosurgery - results from an international research consortium. Radiation Oncology, 6 (1).

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Background: Spinal radiosurgery is a quickly evolving technique in the radiotherapy and neurosurgical communities. However, the methods of spine radiosurgery have not been standardized. This article describes the results of a survey about the methods of spine radiosurgery at five international institutions.Methods: All institutions are members of the Elekta Spine Radiosurgery Research Consortium and have a dedicated research and clinical focus on image-guided radiosurgery. The questionnaire consisted of 75 items covering all major steps of spine radiosurgery.Results: Strong agreement in the methods of spine radiosurgery was observed. In particular, similarities were observed with safety and quality assurance playing an important role in the methods of all institutions, cooperation between neurosurgeons and radiation oncologists in case selection, dedicated imaging for target- and organ-at-risk delineation, application of proper safety margins for the target volume and organs-at-risk, conformal planning and precise image-guided treatment delivery, and close clinical and radiological follow-up. In contrast, three major areas of uncertainty and disagreement were identified: 1) Indications and contra-indications for spine radiosurgery; 2) treatment dose and fractionation and 3) tolerance dose of the spinal cord.Conclusions: Results of this study reflect the current practice of spine radiosurgery in large academic centers. Despite close agreement was observed in many steps of spine radiosurgery, further research in form of retrospective and especially prospective studies is required to refine the details of spinal radiosurgery in terms of safety and efficacy. © 2011 Guckenberger et al; licensee BioMed Central Ltd.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Guckenberger, M
Sweeney, RA
Flickinger, JCjflickin@pitt.eduJFLICKIN
Gerszten, PC
Kersh, R
Sheehan, J
Sahgal, A
Date: 15 December 2011
Date Type: Publication
Journal or Publication Title: Radiation Oncology
Volume: 6
Number: 1
DOI or Unique Handle: 10.1186/1748-717x-6-172
Schools and Programs: School of Medicine > Neurological Surgery
School of Medicine > Radiation Oncology
Refereed: Yes
Date Deposited: 01 Nov 2016 17:04
Last Modified: 04 Feb 2019 22:55


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