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Epigenetics in breast cancer: What's new?

Huang, Y and Nayak, S and Jankowitz, R and Davidson, NE and Oesterreich, S (2011) Epigenetics in breast cancer: What's new? Breast Cancer Research, 13 (6). ISSN 1465-5411

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Epigenetic changes are critical for development and progression of cancers, including breast cancer. Significant progress has been made in the basic understanding of how various epigenetic changes such as DNA methylation, histone modification, miRNA expression, and higher order chromatin structure affect gene expression. The present review will focus on methylation and demethylation of histones. While the acetylation of histones has been at the forefront of well-characterized post-translational modifications of histones, including the development of inhibitors targeting de-acetylating enzymes, the past few years have witnessed a dramatic increase in knowledge regarding the role of histone methylation/demethylation. This is an exciting and rapidly evolving area of research, with much promise for potential clinical intervention in several cancers including breast cancer. We also summarize efforts to identity DNA methylation signatures that could be prognostic and/or predictive markers in breast cancer, focusing on recent studies using genome-wide approaches. Finally, we briefly review the efforts made by both the National Institutes of Health Epigenome Project and The Cancer Genome Atlas, especially highlighting the study of breast cancer epigenetics, exciting technological advances, potential roadblocks, and future directions. © 2010 BioMed Central Ltd.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Huang, Yyih26@pitt.eduYIH26
Nayak, S
Jankowitz, Rrcj8@pitt.eduRCJ8
Davidson, NEned23@pitt.eduNED23
Oesterreich, Ssto16@pitt.eduSTO16
Centers: Other Centers, Institutes, Offices, or Units > Pittsburgh Cancer Institute
Date: 1 November 2011
Date Type: Publication
Journal or Publication Title: Breast Cancer Research
Volume: 13
Number: 6
DOI or Unique Handle: 10.1186/bcr2925
Schools and Programs: School of Medicine > Medicine
School of Medicine > Pharmacology and Chemical Biology
Refereed: Yes
ISSN: 1465-5411
Article Type: Review
Date Deposited: 26 Oct 2016 17:12
Last Modified: 13 Oct 2017 23:55


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