Semiquantitative assessment of subchondral bone marrow edema-like lesions and subchondral cysts of the knee at 3T MRI: A comparison between intermediate-weighted fat-suppressed spin echo and Dual Echo Steady State sequences

Hayashi, D and Guermazi, A and Kwoh, CK and Hannon, MJ and Moore, C and Jakicic, JM and Green, SM and Roemer, FW (2011) Semiquantitative assessment of subchondral bone marrow edema-like lesions and subchondral cysts of the knee at 3T MRI: A comparison between intermediate-weighted fat-suppressed spin echo and Dual Echo Steady State sequences. BMC Musculoskeletal Disorders, 12.

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Abstract

Background: Choice of appropriate MR pulse sequence is important for any research studies using imaging-derived data. The aim of this study was to compare semiquantitative assessment of subchondral bone marrow edema-like lesions and subchondral cysts using intermediate-weighted (IW) fat-suppressed (fs) spin echo and Dual Echo Steady State (DESS) sequences on 3 T MRI. Methods. Included were 201 subjects aged 35-65 with frequent knee pain. 3T MRI was performed with the same sequence protocol as in the Osteoarthritis Initiative (OAI). In a primary reading subchondral bone marrow edema-like lesions were assessed according to the WORMS system. Two hundred subregions with such lesions were randomly chosen. The extent of subchondral bone marrow edema-like lesions was re-evaluated separately using sagittal IW fs and DESS sequences according to WORMS. Lesion size and confidence of the differentiation between subchondral bone marrow edema-like lesions and subchondral cysts located within or adjacent to them was rated from 0 to 3. Wilcoxon signed-rank tests and chi-square statistics were used to examine differences between the two sequences. Results: Of 200 subchondral bone marrow edema-like lesions detected by IW fs sequence, 93 lesions (46.5%) were not depicted by the DESS sequence. The IW fs sequence depicted subchondral bone marrow edema-like lesions to a larger extent than DESS (p < 0.0001), and the opposite was true for subchondral cysts. Confidence scores for differentiation of the two types of lesions were not significantly different between the two sequences. Conclusions: In direct comparison the IW fs sequence depicts more subchondral bone marrow edema-like lesions and better demonstrate the extent of their maximum size. The DESS sequence helps in the differentiation of subchondral bone marrow edema-like lesions and subchondral cysts. The IW fs sequence should be used for determination of lesion extent whenever the size of subchondral bone marrow edema-like lesions is the focus of attention. © 2011Hayashi et al; licensee BioMed Central Ltd.

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Details

Item Type:	Article
Status:	Published
Creators/Authors:	Creators Email Pitt Username ORCID Hayashi, D Guermazi, A Kwoh, CK Hannon, MJ mjh58@pitt.edu MJH58 Moore, C Jakicic, JM jjakicic@pitt.edu JJAKICIC Green, SM Roemer, FW
Date:	14 September 2011
Date Type:	Publication
Journal or Publication Title:	BMC Musculoskeletal Disorders
Volume:	12
DOI or Unique Handle:	10.1186/1471-2474-12-198
Schools and Programs:	School of Health and Rehabilitation Sciences > Health and Rehabilitation Sciences School of Medicine > Immunology
Refereed:	Yes
Date Deposited:	31 Oct 2016 16:39
Last Modified:	03 Feb 2019 04:55
URI:	http://d-scholarship.pitt.edu/id/eprint/30022

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