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The procoagulant effects of fine particulate matter in vivo

Kilinç, E and Schulz, H and Kuiper, GJAJM and Spronk, HMH and ten Cate, H and Upadhyay, S and Ganguly, K and Stoeger, T and Semmler-Bhenke, M and Takenaka, S and Kreyling, WG and Pitz, M and Reitmeir, P and Peters, A and Eickelberg, O and Wichmann, HE (2011) The procoagulant effects of fine particulate matter in vivo. Particle and Fibre Toxicology, 8.

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Inhalation of fine particulate matter (<2.5 μm; fine PM) has been shown to increase the risk for cardiovascular events. In this letter, we reappraise the role of tissue factor (TF) antigen and we also summarize changes in measured coagulation proteins in humans and rodents by other studies with fine PM. By considering all studies including ours, we conclude that monitoring the overall coagulation state by measuring capacity assays such as thrombin generation, and quantification of TF activity would be more suitable than determining single coagulation proteins (such as TF antigen) in order to better assess the systemic prothrombotic effects of fine PM. © 2011 Kilinç et al; licensee BioMed Central Ltd.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Kilinç, E
Schulz, H
Kuiper, GJAJM
Spronk, HMH
ten Cate, H
Upadhyay, Sswu4@pitt.eduSWU4
Ganguly, Kkog8@pitt.eduKOG8
Stoeger, T
Semmler-Bhenke, M
Takenaka, S
Kreyling, WG
Pitz, M
Reitmeir, P
Peters, A
Eickelberg, O
Wichmann, HE
Date: 15 March 2011
Date Type: Publication
Journal or Publication Title: Particle and Fibre Toxicology
Volume: 8
DOI or Unique Handle: 10.1186/1743-8977-8-12
Schools and Programs: School of Public Health > Environmental and Occupational Health
Refereed: Yes
Article Type: Correspondence/Letter
Date Deposited: 31 Oct 2016 16:03
Last Modified: 29 Jan 2019 15:55


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