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Inter-regional connectivity within the win/loss anticipation network in depressed individuals with bipolar disorder, in depressed individuals with major depressive disorder and healthy controls

Manelis, Anna and Chase, Henry W. and Greenberg, Tsafrir and Stiffler, Richelle and Lockovich, Jeanette C and Aslam, Haris and Phillips, Mary L. (2015) Inter-regional connectivity within the win/loss anticipation network in depressed individuals with bipolar disorder, in depressed individuals with major depressive disorder and healthy controls. In: 70th Society of Biological Psychiatry Annual Meeting 2015, Toronto, Canada.

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Abstract

Identifying biomarkers distinguishing depressed individuals with bipolar disorder (BDD) from those with major depressive disorder (MDD) would help to develop better therapeutic strategies and improve treatment outcomes. Depressed individuals are often biased (i.e., pessimistic bias) in their anticipation of future negative outcomes. Goal: to determine the differences in connectivity within the reward anticipation network between BDD, MDD and HC (healthy controls) using a graph modelling method. BDD had denser connectivity among fronto-striatal regions, while MDD had denser connectivity among occipital regions. BDD and MDD had similar fronto-striatal connectivity that was less dense compared to HC. Altered fronto-striatal and occipital connectivity patterns during win anticipation distinguished BDD from MDD and HC and might reflect a neurobiological mechanism for impaired processing of positive stimuli in BDD.


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Details

Item Type: Conference or Workshop Item (Poster)
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Manelis, AnnaANM212@pitt.eduANM2120000-0002-6605-5130
Chase, Henry W.hwc2@pitt.eduHWC2
Greenberg, Tsafrir
Stiffler, Richelle
Lockovich, Jeanette C
Aslam, Haris
Phillips, Mary L.
Date: 8 June 2015
Date Type: Publication
Journal or Publication Title: F1000 Research
Publisher: F1000 Research Ltd.
Event Title: 70th Society of Biological Psychiatry Annual Meeting 2015
Event Type: Conference
Schools and Programs: School of Medicine > Psychiatry
Refereed: No
ISSN: 2046-1402
Official URL: https://f1000research.com/posters/1098070
Additional Information: Competing Interests: No competing interests were disclosed
Date Deposited: 29 Nov 2016 20:21
Last Modified: 30 Oct 2018 14:03
URI: http://d-scholarship.pitt.edu/id/eprint/30117

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