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A neutrophil phenotype model for extracorporeal treatment of sepsis

Malkin, Alexander D. and Sheehan, Robert and Redl, Heinz and Clermont, Gilles (2014) A neutrophil phenotype model for extracorporeal treatment of sepsis. In: 34th International Symposium on Intensive Care and Emergency Medicine (ISICEM) 2014, Brussels, Belgium.

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Abstract

A simplified mechanistic mathematical model of Interleukin-8 (IL-8) mediated activation of CXCR-1/2 receptors was developed using ordinary differential equations. An extracorporeal intervention was then implemented by introducing a trapped receptor state which limits IL-8 signaling through CXCR-1/2. In severe sepsis, an extracorporeal treatment which modulates CXCR-1/2 levels has therapeutic potential, but also potential for harm. Further development of the mathematical model will help guide optimal device development and determine which patient populations should be targeted by treatment.


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Details

Item Type: Conference or Workshop Item (Poster)
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Malkin, Alexander D.alm270@pitt.eduALM270
Sheehan, Robert
Redl, Heinz
Clermont, Gillescler@pitt.eduCLER
Date: 23 April 2014
Date Type: Publication
Journal or Publication Title: F1000 Research
Publisher: F1000 Research Ltd.
Event Title: 34th International Symposium on Intensive Care and Emergency Medicine (ISICEM) 2014
Event Type: Conference
Schools and Programs: School of Medicine > Critical Care Medicine
Swanson School of Engineering > Bioengineering
Refereed: No
ISSN: 2046-1402
Official URL: https://f1000research.com/posters/1095182
Additional Information: Competing Interests: No competing interests were disclosed
Date Deposited: 29 Nov 2016 20:14
Last Modified: 25 Aug 2017 04:56
URI: http://d-scholarship.pitt.edu/id/eprint/30122

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