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Characterization of the binding and neutralizing properties of monoclonal antibodies against JCV

Randhawa, Parmjeet S and Pastrana, Diana V and Ray, U and Buck, Christopher B and Christensen, N (2013) Characterization of the binding and neutralizing properties of monoclonal antibodies against JCV. In: New York Academy of Sciences 2013 - Progressive Multifocal Leukoencephalopathy meeting, 19 June 2013 - 20 June 2013, New York City, New York, USA.

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Abstract

Antibody-based immunity to JC polyomavirus (JCV) is not well understood and monoclonal Antibodies (mAbs) that functionally neutralize the infectivity of JCV have not been documented. (1). Virus Like Particles (VLP)-based ELISAs can detect JCV-binding antibodies that do not necessarily neutralize the infectivity of JCV. Therefore, functional neutralization-based serology will be needed to validate candidate JCV VLP vaccines and therapeutic McAbs. (2). The neutralizing activity of McAbs can be specific for particular genotypes and clinical strains. Hence, VLPs from multiple genotypes may be needed to formulate a vaccine that could protect against diverse JCV strains circulating in patients with progressive multifocal encephalopathy (PML).

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Details

Item Type: Conference or Workshop Item (Poster)
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Randhawa, Parmjeet Spsr@pitt.eduPSR
Pastrana, Diana V
Ray, U
Buck, Christopher B
Christensen, N
Date: 6 August 2013
Date Type: Publication
Journal or Publication Title: F1000 Research
Publisher: F1000 Research Ltd.
Event Title: New York Academy of Sciences 2013 - Progressive Multifocal Leukoencephalopathy meeting
Event Dates: 19 June 2013 - 20 June 2013
Event Type: Conference
Schools and Programs: School of Medicine > Pathology
Refereed: No
ISSN: 2046-1402
Official URL: https://f1000research.com/posters/1093995
Additional Information: Competing Interests: No competing interests were disclosed
Date Deposited: 29 Nov 2016 17:31
Last Modified: 25 Aug 2017 04:56
URI: http://d-scholarship.pitt.edu/id/eprint/30126

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