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An anti-large T-antigen strategy to develop anti-JCV drugs

Randhawa, Parmjeet S and Bueno-Fernandez, M and Seyb, K and Perry, A and Charles, I and Hustus, C and Huang, M and Smith, M and Glickman, MA (2013) An anti-large T-antigen strategy to develop anti-JCV drugs. In: New York Academy of Sciences 2013 - Progressive Multifocal Leukoencephalopathy meeting, 19 June 2013 - 20 June 2013, New York City, New York, USA.

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Abstract

There are currently no JCV-specific therapies available for clinical use. This study evaluates viral large T antigen (LTA) as a potential target for drug development. LTA is a hexameric protein with a helicase activity that is powered by ATP binding and hydrolysis. The helicase and ATPase function is critical for viral replication and inhibition by small molecules would disrupt the viral life cycle. LTA is a valid target for discovery of anti-JCV drugs. The hits identified are reasonable starting points for medicinal chemistry to improve potency and selectivity. Screening of additional chemical libraries could also be considered to identify chemical structures that may be more potent with acceptable cytotoxicity.

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Details

Item Type: Conference or Workshop Item (Poster)
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Randhawa, Parmjeet Spsr@pitt.eduPSR
Bueno-Fernandez, M
Seyb, K
Perry, A
Charles, I
Hustus, C
Huang, M
Smith, M
Glickman, MA
Date: 6 August 2013
Date Type: Publication
Journal or Publication Title: F1000 Research
Publisher: F1000 Research Ltd.
Event Title: New York Academy of Sciences 2013 - Progressive Multifocal Leukoencephalopathy meeting
Event Dates: 19 June 2013 - 20 June 2013
Event Type: Conference
Schools and Programs: School of Medicine > Pathology
Refereed: No
ISSN: 2046-1402
Official URL: https://f1000research.com/posters/1093520
Additional Information: Competing Interests: No competing interests were disclosed
Date Deposited: 29 Nov 2016 17:31
Last Modified: 25 Aug 2017 04:56
URI: http://d-scholarship.pitt.edu/id/eprint/30127

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