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Mitochondria targeting of non-peroxidizable triphenylphosphonium conjugated oleic acid protects mouse embryonic cells against apoptosis: Role of cardiolipin remodeling

Tyurina, YY and Tungekar, MA and Jung, MY and Tyurin, VA and Greenberger, JS and Stoyanovsky, DA and Kagan, VE (2012) Mitochondria targeting of non-peroxidizable triphenylphosphonium conjugated oleic acid protects mouse embryonic cells against apoptosis: Role of cardiolipin remodeling. In: UNSPECIFIED.

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Abstract

Peroxidation of cardiolipin in mitochondria is essential for the execution of apoptosis. We suggested that integration of oleic acid into cardiolipin generates non-oxidizable cardiolipin species hence protects cells against apoptosis. We synthesized mitochondria-targeted triphenylphosphonium oleic acid ester. Using lipidomics analysis we found that pretreatment of mouse embryonic cells with triphenylphosphonium oleic acid ester resulted in decreased contents of polyunsaturated cardiolipins and elevation of its species containing oleic acid residues. This caused suppression of apoptosis induced by actinomycin D. Triacsin C, an inhibitor of acyl-CoA synthase, blocked integration of oleic acid into cardiolipin and restored cell sensitivity to apoptosis. © 2012 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.


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Details

Item Type: Conference or Workshop Item (UNSPECIFIED)
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Tyurina, YYyyt1@pitt.eduYYT1
Tungekar, MA
Jung, MY
Tyurin, VAvtyurin@pitt.eduVTYURIN
Greenberger, JSjoelg@pitt.eduJOELG
Stoyanovsky, DAdas11@pitt.eduDAS110000-0001-5591-4780
Kagan, VEkagan@pitt.eduKAGAN
Date: 3 February 2012
Date Type: Publication
Journal or Publication Title: FEBS Letters
Volume: 586
Number: 3
Page Range: 235 - 241
DOI or Unique Handle: 10.1016/j.febslet.2011.12.016
Schools and Programs: Graduate School of Public Health > Environmental and Occupational Health
Refereed: No
ISSN: 0014-5793
Date Deposited: 22 Nov 2016 17:38
Last Modified: 14 Oct 2017 12:55
URI: http://d-scholarship.pitt.edu/id/eprint/30152

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