Link to the University of Pittsburgh Homepage
Link to the University Library System Homepage Link to the Contact Us Form

From fibroblast cells to cardiomyocytes: Direct lineage reprogramming

Yang, L (2011) From fibroblast cells to cardiomyocytes: Direct lineage reprogramming. Stem Cell Research and Therapy, 2 (1).

Published Version
Available under License : See the attached license file.

Download (203kB) | Preview
[img] Plain Text (licence)
Available under License : See the attached license file.

Download (1kB)


Recent advances in stem cell biology have established the feasibility of reprogramming human and murine fibroblast cells into induced pluripotent stem cells. Three master regulators have been demonstrated to be sufficient in the management of cell status of 'pluripotent' versus 'differentiated'. The same strategy has been used to directly convert one somatic cell type into another cell type, such as the converting of exocrine pancreas cells into cells closely resembling beta cells and the reprogramming of fibroblast cells into functional neuron cells. Srivastava's group reported the first direct reprogramming of mouse fibroblast cells into mesoderm lineage cells (cardiomyocytes) with the enforced expression of three cardiac transcriptional factors: Gata4, Mef2c, and Tbx5. The induced cardiomyocytes exhibit a global gene expression profile and basic electrophysiological characteristics similar to those of postnatal cardiomyocytes. This study made significant advances in cardiovascular and stem cell fields and has important implications in understanding heart developmental biology as well as in potential therapies of human cardiovascular diseases. © 2011 BioMed Central Ltd.


Social Networking:
Share |


Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Yang, Llyang@pitt.eduLYANG
Date: 9 September 2011
Date Type: Publication
Journal or Publication Title: Stem Cell Research and Therapy
Volume: 2
Number: 1
DOI or Unique Handle: 10.1186/scrt42
Schools and Programs: School of Medicine > Developmental Biology
Refereed: Yes
Article Type: Review
Date Deposited: 16 Nov 2016 18:48
Last Modified: 29 Jan 2019 15:55


Monthly Views for the past 3 years

Plum Analytics

Actions (login required)

View Item View Item