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Growth factor regulation of proliferation and survival of multipotential stromal cells

Rodrigues, M and Griffith, LG and Wells, A (2010) Growth factor regulation of proliferation and survival of multipotential stromal cells. Stem Cell Research and Therapy, 1 (4).

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Abstract

Multipotential stromal cells (MSCs) have been touted to provide an alternative to conservative procedures of therapy, be it heart transplants, bone reconstruction, kidney grafts, or skin, neuronal and cartilage repair. A wide gap exists, however, between the number of MSCs that can be obtained from the donor site and the number of MSCs needed for implantation to regenerate tissue. Standard methods of MSC expansion being followed in laboratories are not fully suitable due to time and age-related constraints for autologous therapies, and transplant issues leave questions for allogenic therapies. Beyond these issues of sufficient numbers, there also exists a problem of MSC survival at the graft. Experiments in small animals have shown that MSCs do not persist well in the graft environment. Either there is no incorporation into the host tissue, or, if there is incorporation, most of the cells are lost within a month. The use of growth and other trophic factors may be helpful in counteracting these twin issues of MSC expansion and death. Growth factors are known to influence cell proliferation, motility, survival and morphogenesis. In the case of MSCs, it would be beneficial that the growth factor does not induce differentiation at an early stage since the number of early-differentiating progenitors would be very low. The present review looks at the effect of and downstream signaling of various growth factors on proliferation and survival in MSCs. © 2010 BioMed Central Ltd.


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Rodrigues, M
Griffith, LG
Wells, Aahw6@pitt.eduAHW6
Date: 1 December 2010
Date Type: Publication
Journal or Publication Title: Stem Cell Research and Therapy
Volume: 1
Number: 4
DOI or Unique Handle: 10.1186/scrt32
Schools and Programs: School of Medicine > Pathology
Refereed: Yes
Article Type: Review
Date Deposited: 15 Nov 2016 20:15
Last Modified: 02 Feb 2019 15:55
URI: http://d-scholarship.pitt.edu/id/eprint/30216

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