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Shedding new light on genetic dark matter

Melhem, N and Devlin, B (2010) Shedding new light on genetic dark matter. Genome Medicine, 2 (10).

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Discoveries from genome-wide association studies have contributed to our knowledge of the genetic etiology of many complex diseases. However, these account for only a small fraction of each disease's heritability. Here, we comment on approaches currently available to uncover more of the genetic 'dark matter,' including an approach introduced recently by Naukkarinen and colleagues. These authors propose a method for distinguishing between gene expression driven by genetic variation and that driven by nongenetic factors. This dichotomy allows investigators to focus statistical tests and further molecular analyses on a smaller set of genes, thereby discovering new genetic variation affecting risk for disease. We need more methods like this one if we are to shed a powerful light on dark matter. By enhancing our understanding of molecular genetic etiology, such methods will help us to understand disease processes better and will advance the promise of personalized medicine.© 2010 BioMed Central Ltd.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Melhem, Nnam19@pitt.eduNAM190000-0001-8572-8487
Devlin, Bdevlinbj@pitt.eduDEVLINBJ
Date: 21 October 2010
Date Type: Publication
Journal or Publication Title: Genome Medicine
Volume: 2
Number: 10
DOI or Unique Handle: 10.1186/gm200
Schools and Programs: School of Medicine > Psychiatry
Refereed: Yes
Date Deposited: 15 Nov 2016 20:15
Last Modified: 01 Oct 2019 15:00


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