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Association of an INSIG2 obesity allele with cardiovascular phenotypes is gender and age dependent

Skelding, KA and Gerhard, GS and Vlachos, H and Selzer, F and Kelsey, SF and Chu, X and Erdman, R and Williams, DO and Kip, KE (2010) Association of an INSIG2 obesity allele with cardiovascular phenotypes is gender and age dependent. BMC Cardiovascular Disorders, 10.

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Abstract

Background: The INSIG2 gene has been implicated in cholesterol metabolism and a single nucleotide polymorphism (SNP) near INSIG2 has been shown to be associated with obesity. We sought to determine the relationship of the INSIG2 SNP to cardiovascular disease (CVD) related phenotypes.Methods and Results: Nine hundred forty six patients undergoing percutaneous coronary intervention (PCI) in wave 5 of the multicenter NHLBI Dynamic Registry were genotyped using RT-PCR/TaqMan/allelic discrimination for the rs7566605 SNP near the INSIG2 gene. Clinical variables analyzed include demographics, medical history, and procedural details. The prevalence of peripheral vascular disease (PVD) was significantly higher in older men (≥65 years) who were either homozygous or carriers of the obesity/lipid risk allele ("C") compared to non-carriers (odds ratio 3.4, p = 0.013) using a logistic regression model incorporating history of hypercholesterolemia, history of hypertension, cerebrovascular disease, history of diabetes, and BMI. A similar relationship with cerebrovascular disease was found in older (>65) women (odds ratio 3.4, p = 0.013). The INSIG2 SNP was not associated with BMI, nor with other clinical variables.Conclusion: Age and gender may influence the association of the INSIG2 obesity SNP with PVD and cerebrovascular disease in patients with pre-existing CVD. © 2010 Skelding et al; licensee BioMed Central Ltd.


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Skelding, KA
Gerhard, GS
Vlachos, Hvlachos@edc.pitt.eduVLACHOS
Selzer, F
Kelsey, SFkelsey@edc.pitt.eduKELSEYS
Chu, X
Erdman, R
Williams, DO
Kip, KE
Date: 29 September 2010
Date Type: Publication
Journal or Publication Title: BMC Cardiovascular Disorders
Volume: 10
DOI or Unique Handle: 10.1186/1471-2261-10-46
Schools and Programs: Graduate School of Public Health > Epidemiology
Refereed: Yes
Date Deposited: 14 Nov 2016 21:02
Last Modified: 02 Feb 2019 16:56
URI: http://d-scholarship.pitt.edu/id/eprint/30229

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