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Novel strategies in tendon and ligament tissue engineering: Advanced biomaterials and regeneration motifs.

Kuo, Catherine K and Marturano, Joseph E and Tuan, Rocky S (2010) Novel strategies in tendon and ligament tissue engineering: Advanced biomaterials and regeneration motifs. Sports Med Arthrosc Rehabil Ther Technol, 2. 20 - ?.

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Abstract

Tendon and ligaments have poor healing capacity and when injured often require surgical intervention. Tissue replacement via autografts and allografts are non-ideal strategies that can lead to future problems. As an alternative, scaffold-based tissue engineering strategies are being pursued. In this review, we describe design considerations and major recent advancements of scaffolds for tendon/ligament engineering. Specifically, we outline native tendon/ligament characteristics critical for design parameters and outcome measures, and introduce synthetic and naturally-derived biomaterials used in tendon/ligament scaffolds. We will describe applications of these biomaterials in advanced tendon/ligament engineering strategies including the utility of scaffold functionalization, cyclic strain, growth factors, and interface considerations. The goal of this review is to compile and interpret the important findings of recent tendon/ligament engineering research in an effort towards the advancement of regenerative strategies.


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Kuo, Catherine K
Marturano, Joseph E
Tuan, Rocky Srst13@pitt.eduRST13
Date: 20 August 2010
Date Type: Acceptance
Journal or Publication Title: Sports Med Arthrosc Rehabil Ther Technol
Volume: 2
Page Range: 20 - ?
DOI or Unique Handle: 10.1186/1758-2555-2-20
Schools and Programs: School of Medicine > Orthopaedic Surgery
Refereed: Yes
Date Deposited: 14 Nov 2016 17:40
Last Modified: 31 Jul 2020 18:07
URI: http://d-scholarship.pitt.edu/id/eprint/30243

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