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Mechanics rules cell biology

Wang, JHC and Li, B (2010) Mechanics rules cell biology. Sports Medicine, Arthroscopy, Rehabilitation, Therapy and Technology, 2 (1).

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Cells in the musculoskeletal system are subjected to various mechanical forces in vivo. Years of research have shown that these mechanical forces, including tension and compression, greatly influence various cellular functions such as gene expression, cell proliferation and differentiation, and secretion of matrix proteins. Cells also use mechanotransduction mechanisms to convert mechanical signals into a cascade of cellular and molecular events. This mini-review provides an overview of cell mechanobiology to highlight the notion that mechanics, mainly in the form of mechanical forces, dictates cell behaviors in terms of both cellular mechanobiological responses and mechanotransduction. © 2010 Wang and Li; licensee BioMed Central Ltd.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Wang, JHCwanghc@pitt.eduWANGHC
Li, B
Date: 8 July 2010
Date Type: Publication
Journal or Publication Title: Sports Medicine, Arthroscopy, Rehabilitation, Therapy and Technology
Volume: 2
Number: 1
DOI or Unique Handle: 10.1186/1758-2555-2-16
Schools and Programs: School of Medicine > Orthopaedic Surgery
Refereed: Yes
Article Type: Review
Date Deposited: 10 Nov 2016 18:29
Last Modified: 02 Feb 2019 16:56


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