Howard, Alec J
(2016)
Genetic factors involved in substance use disorders with review of the rising opioid epidemic.
Master Essay, University of Pittsburgh.
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Abstract
Substance use disorders comprise a significant public health burden. In a 2015 survey, the Substance Abuse and Mental Health Services Administration reported that 20.8 million people aged 12 or older had a substance use disorder in the past year. Healthcare expenditure for treatment in the U.S. was reported to cost $24.3 billon in 2009. Research has shown that genetic factors may contribute to the development and maintenance of these disorders. The additive effects of single-nucleotide polymorphisms have been implicated. Epigenetic mechanisms involving microRNA, histone acetylation, and DNA methylation have been evidenced in association with chronic substance use. Further research is necessary to determine the details of underlying mechanisms of susceptibility to addiction. Utilizing evidence-based policy can have a substantial impact on public health outcomes. Concern over rising levels of opioid-related overdose death has warranted changes in health policy. This essay highlights health policy at the federal, state, and local level regarding the opioid epidemic.
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Details
Item Type: |
Other Thesis, Dissertation, or Long Paper
(Master Essay)
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Status: |
Unpublished |
Creators/Authors: |
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Contributors: |
Contribution | Contributors Name | Email | Pitt Username | ORCID ![](/images/orcid_id_24x24.png) |
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Committee Chair | Kammerer, Candace | cmk3@pitt.edu | cmk3 | UNSPECIFIED | Committee Member | Martinson, Jeremy | jmartins@pitt.edu | jmartins | UNSPECIFIED |
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Date: |
16 December 2016 |
Date Type: |
Publication |
Publisher: |
University of Pittsburgh |
Institution: |
University of Pittsburgh |
Schools and Programs: |
School of Public Health > Human Genetics |
Degree: |
MPH - Master of Public Health |
Thesis Type: |
Master Essay |
Refereed: |
Yes |
Date Deposited: |
22 May 2017 20:54 |
Last Modified: |
02 Jul 2024 10:55 |
URI: |
http://d-scholarship.pitt.edu/id/eprint/30408 |
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