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Fabrication and In Vitro Testing of Synthetic Arterial Grafts

Gao, Ya (2017) Fabrication and In Vitro Testing of Synthetic Arterial Grafts. Master's Thesis, University of Pittsburgh. (Unpublished)

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Abstract

Cardiovascular diseases (CVD) is now the main cause for death around the world. One of the major treatment to it is bypass grafting using a synthetic graft or patient’s own blood vessels to bypass the blocked area. However, the existing prosthetic graft for this surgery has poor long-term patency, i.e. does not remain open for extended periods. The failure of existing graft is the result of platelet adhesion, which forms clots and then restricts blood flow. The purpose of this thesis is to introduce a new-generation synthetic graft which is flexible with an internal topography that changes continually due to normal pulse pressure oscillations. This thesis describes fabrication of such grafts, quantifies their expansion and contraction under pulsatile flow, and tests whether it reduces bio-fouling. The thesis also discusses the design strategy for such grafts so that they can work under certain pressure with a controlled deformation. Finally, we validate grafts with whole blood and platelet rich plasma to find out whether they reduce biofouling in vitro, also as a prelude to animal experiments.


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Details

Item Type: University of Pittsburgh ETD
Status: Unpublished
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Gao, Yayag33@pitt.eduyag33
ETD Committee:
TitleMemberEmail AddressPitt UsernameORCID
Thesis AdvisorVelankar, Sachinvelankars@gmail.com
Committee MemberRobertson, Annerbertson@pitt.edu
Committee MemberMccarthy, Josephjjmcc@pitt.edu
Date: 13 June 2017
Date Type: Publication
Defense Date: 29 March 2017
Approval Date: 13 June 2017
Submission Date: 7 April 2017
Access Restriction: No restriction; Release the ETD for access worldwide immediately.
Number of Pages: 69
Institution: University of Pittsburgh
Schools and Programs: Swanson School of Engineering > Chemical and Petroleum Engineering
Degree: MS - Master of Science
Thesis Type: Master's Thesis
Refereed: Yes
Uncontrolled Keywords: synthetic graft
Date Deposited: 13 Jun 2017 14:35
Last Modified: 13 Jun 2017 14:35
URI: http://d-scholarship.pitt.edu/id/eprint/31378

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