Jeffries, Marisa
(2017)
ERK1/ 2 Activation in Preexisting Oligodendrocytes of Adult Mice Drives New Myelin Synthesis and Enhanced CNS Function.
Master's Thesis, University of Pittsburgh.
(Unpublished)
Abstract
Growing evidence shows that mechanisms controlling CNS plasticity extend beyond the synapse
and that alterations in myelin can modify conduction velocity, leading to changes in neural
circuitry. Although it is widely accepted that newly generated oligodendrocytes (OLs) produce
myelin in the adult CNS, the contribution of preexisting OLs to functional myelin remodeling is
not known. Here, we show that sustained activation of extracellular signal-regulated kinases 1
and 2 (ERK1/2) in preexisting OLs of adult mice is sufficient to drive increased myelin
thickness, faster conduction speeds, and enhanced hippocampal-dependent emotional learning.
Although preexisting OLs do not normally contribute to remyelination, we show that sustained
activation of ERK1/2 renders them able to do so. These data suggest that strategies designed to
push mature OLs to reinitiate myelination may be beneficial both for enhancing remyelination in
demyelinating diseases and for increasing neural plasticity in the adult CNS.
Share
Citation/Export: |
|
Social Networking: |
|
Details
Item Type: |
University of Pittsburgh ETD
|
Status: |
Unpublished |
Creators/Authors: |
|
ETD Committee: |
|
Date: |
18 April 2017 |
Date Type: |
Publication |
Defense Date: |
22 December 2016 |
Approval Date: |
18 April 2017 |
Submission Date: |
18 April 2017 |
Access Restriction: |
No restriction; Release the ETD for access worldwide immediately. |
Number of Pages: |
55 |
Institution: |
University of Pittsburgh |
Schools and Programs: |
School of Medicine > Neurobiology |
Degree: |
PhD - Doctor of Philosophy |
Thesis Type: |
Master's Thesis |
Refereed: |
Yes |
Uncontrolled Keywords: |
myelin, oligodendrocyte, remyelination |
Date Deposited: |
18 Apr 2017 19:44 |
Last Modified: |
19 Apr 2017 05:15 |
URI: |
http://d-scholarship.pitt.edu/id/eprint/31498 |
Metrics
Monthly Views for the past 3 years
Plum Analytics
Actions (login required)
|
View Item |