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Provider knowledge of non-invasive prenatal testing: a survey of obstetricians

Griffenkranz, Emily (2017) Provider knowledge of non-invasive prenatal testing: a survey of obstetricians. Master's Thesis, University of Pittsburgh. (Unpublished)

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Abstract

Following its introduction to clinical use, noninvasive prenatal testing (NIPT) has dramatically altered the landscape of prenatal screening. Due to its high detection rate of trisomies 21, 18, and 13, along with sex chromosome aneuploidies, many patients are choosing NIPT over traditional screening and diagnostic methods. Previously, this testing was offered to women whose pregnancies were at an increased risk for aneuploidies. Now, guidelines from professional organizations recommend that NIPT should be included as a screening option for all pregnant women. Additionally, laboratories have started to expand NIPT to include microdeletions and microduplications, and are investigating the detection of monogenic disorders as well.
With the rapid introduction of NIPT, surveying health care providers can help to determine how screening guidelines are being implemented in the clinical setting, an important aspect of two of the core public health functions: policy development and assurance. This project assessed obstetricians’ knowledge of NIPT, their readiness for offering NIPT to all women during pregnancy, and the expansion of NIPT testing options through an online survey conducted from February 3, 2017 to March 20, 2017. The survey was distributed to 4,770 ACOG members via their professional list serve and was completed by 238 participants. Results found that most participants demonstrated accurate knowledge of NIPT, but there was a discordance between clinical practice and current guidelines about offering NIPT to the general obstetric population as 45.72% indicted not offering NIPT to low-risk patients. Additionally, when asked about expanded NIPT options, 54.08% indicated that they were not confident in test interpretation and 54.54% were not confident in their explanation of results to patients. This coincided with respondents expressing a preference for choosing what, if any, expanded testing should be offered to patients. Overall, participant confidence and comfort declined with expanded testing. Informational material and educational support regarding expanded NIPT testing should be developed for obstetricians.


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Details

Item Type: University of Pittsburgh ETD
Status: Unpublished
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Griffenkranz, Emilyemg88@pitt.eduemg88
ETD Committee:
TitleMemberEmail AddressPitt UsernameORCID
Thesis AdvisorDurst, Andreaadurst@pitt.edu
Committee MemberGrubs, Robinrgrubs@pitt.edu
Committee MemberFinegold, David Ndnf@pitt.eduDNF
Committee MemberPeters, David Gdgp6@pitt.eduDGP6
Date: 30 August 2017
Date Type: Publication
Defense Date: 3 May 2017
Approval Date: 30 August 2017
Submission Date: 5 June 2017
Access Restriction: 2 year -- Restrict access to University of Pittsburgh for a period of 2 years.
Number of Pages: 106
Institution: University of Pittsburgh
Schools and Programs: Graduate School of Public Health > Genetic Counseling
Degree: MS - Master of Science
Thesis Type: Master's Thesis
Refereed: Yes
Uncontrolled Keywords: NIPT, non-invasive prenatal testing, prenatal screening, cell free DNA, obstetricians
Date Deposited: 30 Aug 2017 21:40
Last Modified: 01 Jul 2019 05:15
URI: http://d-scholarship.pitt.edu/id/eprint/32519

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