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Patil, Avinash (2017) SELF-ASSEMBLED ALKYLSILANE COATINGS FOR RESORBABLE BIOMEDICAL DEVICES. Doctoral Dissertation, University of Pittsburgh. (Unpublished)

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Magnesium (Mg) and its alloys are excellent candidate materials for resorbable biomedical
devices. They are lightweight, biocompatible, osteoinductive and have mechanical properties
similar to bone. Most importantly, they can degrade in the body, eliminating the need for device
removal surgeries, thus reducing potential complications, patient pain and suffering, and
relieving the burden on the healthcare system. The major roadblock for wide implementation of
Mg implantable devices is the initial rapid corrosion of the devices, which causes formation of
gas pocket around the implant. This can impede healing. One strategy to overcome this problem
is use of anticorrosion coatings. We have developed alkylsilane (AS) self-assembled multilayer
coatings to control Mg corrosion, increase the biocompatibility of Mg and be further
functionalized with bioactive molecules. AS coatings are formed by copolymerization of n-
Decyltriethoxysilane and Tetramethoxysilane followed by a dip coating of Mg discs. Some of
them were further functionalized with (3-Aminopropyl) triethoxysilane. Structural, chemical and
anticorrosive properties of the AS coatings were assessed by numerous characterization
techniques. The resulting coatings comprised of highly homogeneous 1 mm thin layers that
significantly reduced corrosion in vitro and in vivo. In vitro and in vivo studies demonstrated the
coating’s high cytocompatibility and low toxicity. Furthermore, the in vivo studies demonstrated
that AS coatings could slow gas bubble formation around implanted Mg devices. Overall, our
study demonstrates that AS coatings can be used to control corrosion of resorbable Mg devices.


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Item Type: University of Pittsburgh ETD
Status: Unpublished
CreatorsEmailPitt UsernameORCID
Patil, Avinashajp79@pitt.eduajp79
ETD Committee:
TitleMemberEmail AddressPitt UsernameORCID
Committee ChairBeniash,
Committee MemberSfeir, Charles
Committee MemberKumta, Prashant
Committee MemberTracy Cui, Xinyan
Committee MemberGawalt, Ellen
Date: 26 September 2017
Date Type: Publication
Defense Date: 19 June 2017
Approval Date: 26 September 2017
Submission Date: 26 July 2017
Access Restriction: 1 year -- Restrict access to University of Pittsburgh for a period of 1 year.
Number of Pages: 144
Institution: University of Pittsburgh
Schools and Programs: Swanson School of Engineering > Bioengineering
Degree: PhD - Doctor of Philosophy
Thesis Type: Doctoral Dissertation
Refereed: Yes
Uncontrolled Keywords: Magnesium, AZ31, resorbable, implant, alkylsilane, coating, corrosion, self-assembly, cytocompatibility
Date Deposited: 26 Sep 2018 05:00
Last Modified: 26 Sep 2018 05:15

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