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The Localized Scleroderma Quality Of Life Instrument (LOSQI): A Disease-Specific Survey Using Anchoring Vignettes

Zigler, Christina (2017) The Localized Scleroderma Quality Of Life Instrument (LOSQI): A Disease-Specific Survey Using Anchoring Vignettes. Doctoral Dissertation, University of Pittsburgh. (Unpublished)

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The main goal of this project was to develop and provide validity evidence for a disease- specific quality of life survey to be used with pediatric localized scleroderma (LS) patients. This new survey, called the Localized Scleroderma Quality of Life Instrument (LoSQI), incorporated unique features associated with the disease, not captured by current surveys. As a secondary goal, the feasibility and usefulness of anchoring vignettes with pediatric patients were examined. The project included three phases; content domain development and item generation, a pilot study, and a field test. Validity evidence was gathered from multiple sources including test content, internal structure, and in relation to other variables. Overall, there was initial support for use of the LoSQI with pediatric LS patients. Patients indicated general understanding and readability of the items, and there was qualitative evidence for content validity. Exploratory factor analysis suggested the utility of reporting a total score along with two subscale scores, (1) Pain and Physical Functioning and (2) Body Image and Social Support. Reliability of both the subscale and total scores was acceptable. There was less evidence for use of anchoring vignettes in this context, as there was a high frequency of ties in rankings, which limited the utility of statistical models. Despite limitations from a small sample size and skewed response distributions, the pilot study and the field test provided promising initial evidence that the LoSQI can be used to capture HRQoL in LS patients ages 10-20 years. Future studies should examine responsiveness of the scores to change and optimal capture of HRQoL in patients <10 years of age.


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Item Type: University of Pittsburgh ETD
Status: Unpublished
CreatorsEmailPitt UsernameORCID
Zigler, Christinacek53@pitt.educek53
ETD Committee:
TitleMemberEmail AddressPitt UsernameORCID
Committee CoChairLane, Suzannesl@pitt.eduSL
Committee CoChairStone, Clementcas@pitt.eduCAS
Committee MemberTorok,
Committee MemberYu, Lanyul2@pitt.eduyul2
Date: 28 September 2017
Date Type: Publication
Defense Date: 26 August 2017
Approval Date: 28 September 2017
Submission Date: 2 August 2017
Access Restriction: No restriction; Release the ETD for access worldwide immediately.
Number of Pages: 238
Institution: University of Pittsburgh
Schools and Programs: School of Education > Psychology in Education
Degree: PhD - Doctor of Philosophy
Thesis Type: Doctoral Dissertation
Refereed: Yes
Uncontrolled Keywords: localized scleroderma, validity, patient reported outcomes, reliability, anchoring vignettes, health related quality of life
Date Deposited: 28 Sep 2017 20:19
Last Modified: 28 Sep 2017 20:19


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