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Efficacy of Platelet-Rich Fibrin on Wound Healing and Pain following Guided Bone Regeneration

Park, Sohyun (2017) Efficacy of Platelet-Rich Fibrin on Wound Healing and Pain following Guided Bone Regeneration. Master's Thesis, University of Pittsburgh. (Unpublished)

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Purpose: The purpose of this study was to evaluate the effect of platelet-rich fibrin (PRF) on the soft tissue wound healing and postoperative pain when it is used as an adjunct therapy for guided bone regeneration (GBR) procedures.

Materials and Methods: Seven patients were randomly assigned to test group (GBR + PRF; n=5) and control group (GBR only; n=2), and soft tissue healing and pain levels were evaluated. Routine GBR procedures using dPTFE membranes were performed for control group. For the test group, the liquid-form PRF was mixed with bone graft materials and PRF membranes were placed on top of the dPTFE membrane. Following surgery, patients in both groups were given a visual analog scale (100 mm) to use for rating their pain level every night for the next week. Post-operative appointments were scheduled at weeks 1, 2, 4, 6, 8, 12, and 16. During the post-operative appointments, the soft tissue healings were evaluated. The present report follows patients for the first 6 weeks post-GBR surgery.

Results: Patients in the test group showed a more rapid decline in self-reported pain, with ratings for the test group being substantially lower than those for the control group. Whereas no membrane exposure was noted for either control patient, exposure was noted for two of the five test patients during follow-up visits. In contrast to membrane exposure, evidence of gingival inflammation was noted in all patients. Similar to the findings for membrane exposure, abnormality in soft tissue consistency was noted for participants in the test group only, mainly in the exposure patients.

Conclusion: The present study suggests that addition of PRF to GBR procedures may lower the postoperative pain level. But due to the small sample size, it was difficult to draw a conclusion on the effect of PRF on the membrane exposure and other soft tissue parameters. After additional data are collected by the next investigator, we may be able to draw more definitive conclusions. The next report will also look at the bone quality and quantity in the histologic and radiographic analysis.


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Item Type: University of Pittsburgh ETD
Status: Unpublished
CreatorsEmailPitt UsernameORCID
Park, Sohyunsop21@pitt.edusop21
ContributionContributors NameEmailPitt UsernameORCID
Committee ChairWilliams, KellyKellyWilliams@pitt.eduUNSPECIFIEDUNSPECIFIED
Committee MemberKumar, Satishsatish.kumar@pitt.eduUNSPECIFIEDUNSPECIFIED
Committee MemberPotluri, Anithaanp60@pitt.eduUNSPECIFIEDUNSPECIFIED
Committee MemberRay, Herberthlr21@pitt.eduUNSPECIFIEDUNSPECIFIED
ETD Committee:
TitleMemberEmail AddressPitt UsernameORCID
Committee ChairWilliams,
Committee MemberKumar,
Committee MemberPotluri,
Committee MemberRay,
Date: 7 August 2017
Defense Date: 11 July 2017
Approval Date: 17 August 2017
Submission Date: 11 August 2017
Access Restriction: 3 year -- Restrict access to University of Pittsburgh for a period of 3 years.
Number of Pages: 50
Institution: University of Pittsburgh
Schools and Programs: School of Dental Medicine > Dental Science
Degree: MDS - Master of Dental Science
Thesis Type: Master's Thesis
Refereed: No
Uncontrolled Keywords: PRF, platelet-rich fibrin, GBR, guided bone regeneration, nonresorbable membrane, dPTFE, pain, soft tissue healing, membrane exposure, Bio-Oss
Article Type: Research Article
Date Deposited: 17 Aug 2017 19:47
Last Modified: 17 Aug 2020 05:15

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  • Efficacy of Platelet-Rich Fibrin on Wound Healing and Pain following Guided Bone Regeneration. (deposited 17 Aug 2017 19:47) [Currently Displayed]


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