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Low Iris and Anterior Chamber Volume Associated with Deepening after Laser Peripheral Iridotomy in Primary Angle Closure Suspects

Esfandiari, Hamed and Amouhashemi, Nassim and Yaseri, Mehdi and Torkian, Pooya and Pakravan, Mohammad and Jadidi, Khosrow and Loewen, Nils A. (2017) Low Iris and Anterior Chamber Volume Associated with Deepening after Laser Peripheral Iridotomy in Primary Angle Closure Suspects. (Submitted)

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Purpose: To evaluate the association between baseline ocular variables and the opening of the anterior chamber angle by laser peripheral iridotomy (LPI) in primary angle closure suspects (PACS) using a new Fourier-domain swept-source anterior segment optical coherence tomography (FD-ASOCT).
Method: Sixty-six PACS eyes of 41 individuals were included in this prospective interventional case series. An FD-ASOCT (Casia SS-1000 OCT; Tomey, Nagoya, Japan) was used to measure biometric baseline variables and at one month after the LPI. Paired t-test was used to compare the difference between pre-and post-LPI measurements. Multivariate regression analysis was used to test for an association between baseline iris thickness and volume, anterior chamber depth and volume, and lens vault with a widening of the angle after an LPI.
Results: The mean age of participants was 58.6 ± 8.7 years, 682% of whom were female. The angle opening distance, recess area and trabecular iris surface area at 500 microns increased by 48 to 73% (all p<0.001). Lens vault and iris volume did not change. A low anterior chamber volume and low iris volume were associated with angle greater deepening by LPI.
Conclusion: Eyes with a shallow anterior chamber and thinner irises are more likely to experience angle opening from an LPI.


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Item Type: Article
Status: Submitted
CreatorsEmailPitt UsernameORCID
Esfandiari, Hamed
Amouhashemi, Nassim
Yaseri, Mehdi
Torkian, Pooya
Pakravan, Mohammad
Jadidi, Khosrow
Loewen, Nils A.nal58@pitt.eduNAL580000-0001-7167-1213
Date: 17 November 2017
Date Type: Publication
Schools and Programs: School of Medicine > Ophthalmology
Refereed: No
Article Type: Research Article
MeSH Headings: angle closure glaucoma; iridotomy; glaucoma; glaucoma laser; anterior segment OCT
Date Deposited: 20 Nov 2017 15:22
Last Modified: 20 Nov 2017 15:22


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