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An exploratory study of sleep-wake disturbance in older patients undergoing induction chemotherapy treatment for newly diagnosed acute myeloid leukemia

Sifang, Zhao (2018) An exploratory study of sleep-wake disturbance in older patients undergoing induction chemotherapy treatment for newly diagnosed acute myeloid leukemia. Master's Thesis, University of Pittsburgh. (Unpublished)

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Abstract

Acute Myeloid Leukemia (AML) is a rare disease occurs more in older adults, with a median age at diagnosis of over 65 years. It is essential to get sufficient sleep, because cancer treatments, like chemotherapy, can be exhausting and physically depleting. Elderly individuals are more likely to have difficulties falling and staying asleep compared with younger adults. To better understand sleep disturbances in older patients with acute myeloid leukemia, this thesis compares differences in sleep-wake disturbances between patients undergoing induction chemotherapy treatment and healthy community individuals. Forty patients newly diagnosed with AML and seventy-five age- gender-matched healthy community individuals had their objective sleep-wake pattern recorded by wrist actigraph devices. Repeated measures of total sleep time, wake after sleep onset, and sleep duration was taken daily for fourteen days. The difference between the two groups and its dependence on time during treatment were compared with a mixed effect ANOVA model. While there is no significant statistical pattern for all three variables over time, all three models showed statistically significant group difference, with patients sleeping on average 17.19 minutes more, spending 61.63 minutes more awake after initial sleep onset, and spending 84.19 minutes more in bed each night.
Public Health Significance: The result of this thesis can be used to inform interventions to improve sleep in cancer patients.


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Details

Item Type: University of Pittsburgh ETD
Status: Unpublished
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Sifang, Zhaosiz14@pitt.edusiz140000-0001-6474-1404
ETD Committee:
TitleMemberEmail AddressPitt UsernameORCID
Committee ChairKrafty, Robertrkrafty@pitt.edu
Committee MemberYouk, Adaayouk@pitt.edu
Committee MemberDana, Bovbjergbovbjergdh@upmc.edu
Date: 30 January 2018
Date Type: Publication
Defense Date: 4 December 2017
Approval Date: 30 January 2018
Submission Date: 27 November 2017
Access Restriction: No restriction; Release the ETD for access worldwide immediately.
Number of Pages: 36
Institution: University of Pittsburgh
Schools and Programs: Graduate School of Public Health > Biostatistics
Degree: MS - Master of Science
Thesis Type: Master's Thesis
Refereed: Yes
Uncontrolled Keywords: Sleep-Wake Disturbance, Older Patients, Chemotherapy Treatment, Acute Myeloid Leukemia
Date Deposited: 30 Jan 2018 22:40
Last Modified: 30 Jan 2018 22:40
URI: http://d-scholarship.pitt.edu/id/eprint/33459

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