Sifang, Zhao
(2018)
An exploratory study of sleep-wake disturbance in older patients undergoing induction chemotherapy treatment for newly diagnosed acute myeloid leukemia.
Master's Thesis, University of Pittsburgh.
(Unpublished)
Abstract
Acute Myeloid Leukemia (AML) is a rare disease occurs more in older adults, with a median age at diagnosis of over 65 years. It is essential to get sufficient sleep, because cancer treatments, like chemotherapy, can be exhausting and physically depleting. Elderly individuals are more likely to have difficulties falling and staying asleep compared with younger adults. To better understand sleep disturbances in older patients with acute myeloid leukemia, this thesis compares differences in sleep-wake disturbances between patients undergoing induction chemotherapy treatment and healthy community individuals. Forty patients newly diagnosed with AML and seventy-five age- gender-matched healthy community individuals had their objective sleep-wake pattern recorded by wrist actigraph devices. Repeated measures of total sleep time, wake after sleep onset, and sleep duration was taken daily for fourteen days. The difference between the two groups and its dependence on time during treatment were compared with a mixed effect ANOVA model. While there is no significant statistical pattern for all three variables over time, all three models showed statistically significant group difference, with patients sleeping on average 17.19 minutes more, spending 61.63 minutes more awake after initial sleep onset, and spending 84.19 minutes more in bed each night.
Public Health Significance: The result of this thesis can be used to inform interventions to improve sleep in cancer patients.
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Details
| Item Type: |
University of Pittsburgh ETD
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| Status: |
Unpublished |
| Creators/Authors: |
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| ETD Committee: |
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| Date: |
30 January 2018 |
| Date Type: |
Publication |
| Defense Date: |
4 December 2017 |
| Approval Date: |
30 January 2018 |
| Submission Date: |
27 November 2017 |
| Access Restriction: |
No restriction; Release the ETD for access worldwide immediately. |
| Number of Pages: |
36 |
| Institution: |
University of Pittsburgh |
| Schools and Programs: |
School of Public Health > Biostatistics |
| Degree: |
MS - Master of Science |
| Thesis Type: |
Master's Thesis |
| Refereed: |
Yes |
| Uncontrolled Keywords: |
Sleep-Wake Disturbance, Older Patients, Chemotherapy Treatment, Acute Myeloid Leukemia |
| Date Deposited: |
30 Jan 2018 22:40 |
| Last Modified: |
30 Jan 2018 22:40 |
| URI: |
http://d-scholarship.pitt.edu/id/eprint/33459 |
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