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A Retrospective Case Review of Soft Tissue Oral Malignancies & Associated Clinicopathologic Features (1991-2016)

Alkeheli, Madawi and Bilodeau, Elizabeth (2017) A Retrospective Case Review of Soft Tissue Oral Malignancies & Associated Clinicopathologic Features (1991-2016). Master's Thesis, University of Pittsburgh. (Unpublished)

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Intraoral soft tissue masses can clinically present as benign, premalignant, or malignant lesions. Variability in presentation of soft tissue masses bear the possibility of misdiagnosis not only by general dentists but also by specialists. After a differential diagnosis is formulated, histopathologic evaluation is essential for establishing a definitive diagnosis.
Neoplastic oral lesions in their early stages are subtle, which can make diagnosis challenging. Dentists play a vital role in the prevention of oral malignancy by early detection, and a thorough understanding of the diagnostic features. However, as most intraoral pathology is benign, clinicians frequently do not include malignancy in their differential diagnosis for soft tissue masses.1 The aim of this study is to emphasize the need of for histologic diagnosis of seemingly benign soft oral lesions as the clinical impression may not be accurate.2-6
It is hypothesized that there will be a large number (~5%) of false negative diagnoses. Cases in which the clinical diagnosis is a benign entity (e.g. fibroma or pyogenic granuloma) but, upon histologic confirmation the pathologic diagnosis of a malignant soft tissue mass. We will also identify which clinical features (i.e. size, color, or clinical differential diagnoses) were most commonly diagnostic pitfalls. The purpose of the study is to elucidate the features most commonly associated with malignancy.


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Item Type: University of Pittsburgh ETD
Status: Unpublished
CreatorsEmailPitt UsernameORCID
Alkeheli, Madawimfa29@pitt.edumfa29
ETD Committee:
TitleMemberEmail AddressPitt UsernameORCID
Thesis AdvisorBilodeau,
Date: 19 December 2017
Date Type: Publication
Defense Date: 14 December 2017
Approval Date: 19 December 2017
Submission Date: 4 December 2017
Access Restriction: 1 year -- Restrict access to University of Pittsburgh for a period of 1 year.
Number of Pages: 37
Institution: University of Pittsburgh
Schools and Programs: School of Dental Medicine > Dental Science
Degree: MS - Master of Science
Thesis Type: Master's Thesis
Refereed: Yes
Uncontrolled Keywords: SCC misdiagnosis benign malignancy clinical features oral malignancy
Date Deposited: 19 Dec 2017 15:14
Last Modified: 19 Dec 2018 06:15


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