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Comparison of swallowing outcomes in single vs. double lung transplant recipients

Pomfret, Sarah and Coyle, James and Sejdić, Ervin and Shaiman, Susan (2018) Comparison of swallowing outcomes in single vs. double lung transplant recipients. Master's Thesis, University of Pittsburgh. (Unpublished)

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Abstract

Swallowing is a physiologically complex, kinematic process that requires highly coordinated activity of numerous nerves and muscles to execute efficient transport of a bolus from the oral cavity to the stomach. Dysphagia, or a difficulty with swallowing, is a concern following lung transplantation due to the high risk of recurrent laryngeal nerve damage, required levels of life-long immunosuppression, and upper airway trauma secondary to prolonged endotracheal intubation (Pomfret, 2016). Post-operatively, repetitive aspiration events can lead to the development of Bronchiolitis Obliterans Syndrome (BOS), a major contributing factor in acute allograft rejection and long-term failure of lung allograft function. The goal of this descriptive, retrospective study is to describe the characteristics of double lung transplant (DLT) swallows through analysis of kinematic swallow durations, airway protection, and physiologic swallow impairments. These results are compared to single lung transplant (SLT) swallow characteristics and two previously published, historical normal cohorts. By explicitly describing the swallow physiology of DLT and SLT recipients, clinically significant risk factors have been identified to assist clinicians and researchers in the development and implementation of better treatment options and safer swallowing strategies post-operatively. These efforts can improve the functional lifespan of the newly transplanted organ and increase patient quality of life.


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Details

Item Type: University of Pittsburgh ETD
Status: Unpublished
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Pomfret, SarahSAP87@pitt.eduSAP87
Coyle, Jamesjcoyle@pitt.eduJCOYLE
Sejdić, Ervinesejdic@pitt.eduESEJDIC0000-0003-4987-8298
Shaiman, Susanshaiman@pitt.eduSHAIMAN
ETD Committee:
TitleMemberEmail AddressPitt UsernameORCID
Committee ChairCoyle, Jamesjcoyle@pitt.eduJCOYLE
Committee MemberSejdic, Ervinesejdic@pitt.eduESEJDIC
Committee MemberShaiman, Susanshaiman@pitt.eduSHAIMAN
Date: 25 May 2018
Date Type: Publication
Defense Date: 30 January 2018
Approval Date: 25 May 2018
Submission Date: 1 March 2018
Access Restriction: 5 year -- Restrict access to University of Pittsburgh for a period of 5 years.
Number of Pages: 61
Institution: University of Pittsburgh
Schools and Programs: School of Health and Rehabilitation Sciences > Communication Science and Disorders
Degree: MS - Master of Science
Thesis Type: Master's Thesis
Refereed: Yes
Uncontrolled Keywords: Dysphagia, Lung Transplant, Swallowing
Date Deposited: 25 May 2018 13:13
Last Modified: 25 May 2018 13:13
URI: http://d-scholarship.pitt.edu/id/eprint/33847

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