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A pharmacogenomic approach to antiplatelet therapy following percutaneous coronary intervention: a review

Iasella, Carlo J (2018) A pharmacogenomic approach to antiplatelet therapy following percutaneous coronary intervention: a review. Master Essay, University of Pittsburgh.

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Abstract

Coronary artery disease is a substantial public health concern in the United States. Clopidogrel, an oral, antiplatelet medication, is a mainstay of medical therapy, but its activity is dependent on the CYP2C19 enzyme. Enzyme activity varies across the population based on variability in CYP2C19 alleles that can lead to loss of enzyme activity. Prasugrel and ticagrelor are newer alternatives to clopidogrel that avoid pharmacogenomic concerns but are more expensive and may be associated with more bleeding. This review aims to evaluate the existing literature surrounding the role of pharmacogenomics in the management of patients who require oral P2Y12 inhibitor therapy, discuss the implementation of clinical programs to promote a personalized medicine-based approach utilizing pharmacogenomics, and describe challenges and future directions for pharmacogenomics-based practice models.


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Details

Item Type: Other Thesis, Dissertation, or Long Paper (Master Essay)
Status: Unpublished
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Iasella, Carlo Jcji12@pitt.educji12
Contributors:
ContributionContributors NameEmailPitt UsernameORCID
Committee ChairFinegold, David N.dnf@pitt.eduUNSPECIFIEDUNSPECIFIED
Committee MemberCoons, James C.jccoons@pitt.eduUNSPECIFIEDUNSPECIFIED
Date: 23 April 2018
Date Type: Submission
Submission Date: 30 March 2018
Access Restriction: No restriction; Release the ETD for access worldwide immediately.
Number of Pages: 30
Institution: University of Pittsburgh
Schools and Programs: Graduate School of Public Health > Multidisciplinary MPH
Degree: MPH - Master of Public Health
Thesis Type: Master Essay
Refereed: Yes
Uncontrolled Keywords: Pharmacogenomics P2Y12 Clopidogrel Percutaneous coronary intervention Coronary artery disease
Date Deposited: 31 May 2019 17:23
Last Modified: 31 May 2019 17:23
URI: http://d-scholarship.pitt.edu/id/eprint/33992

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