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Genetics of the relationship between periodontitis and cardiovascular disease

Verbiar, Julia L. (2018) Genetics of the relationship between periodontitis and cardiovascular disease. Master's Thesis, University of Pittsburgh. (Unpublished)

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Abstract

Objective: It has been proposed that periodontitis and cardiovascular disease are related through a similar underlying inflammation pathway. There has also been suggestion of a genetic etiology connecting the two conditions. Further clarification of this proposed relationship has public health significance as both diseases affect over a quarter of the adult population of the United States. Using data from the Center from Oral Health Research in Appalachia cohort, we examined the relationship between periodontitis and cardiovascular disease. We then tested their association to candidate genetic loci to assess if the genetic loci may explain part of the relationship between the conditions.
Methods and Results: Three indicators of periodontitis were developed; a molecular testing-based variable (BANA, n=970) and two probing depth measurements, a liberal approximation that considered missing teeth as missing due to periodontitis (n=973) and a conservative one that did not (n=961). Personal and family history of heart disease and high blood pressure were condensed into a composite score indicative of cardiovascular disease (n=973). Four candidate single nucleotide polymorphisms (SNPs) were identified in the literature as related to both periodontitis and cardiovascular disease: rs10864294, rs4252120, rs1800795, and rs10965215. Regression models were used to test the association between periodontitis and cardiovascular disease indicators and candidate SNPs with and without adjustment for covariates including age, sex, race, smoking status, and body mass index. Periodontitis and cardiovascular disease proxies were significantly associated with each other in unadjusted models (p<0.050). Heart disease score was not significantly associated with any candidate SNP, but both conservative and liberal probing depth-based indicators had a significant association with rs10864294 in models adjusted for covariates (p=0.003, p=0.006). BANA did not demonstrate a significant association with heart disease score or any candidate SNP.
Conclusions: This study yielded support of the relationship between periodontitis and cardiovascular disease, but not an extension to the genetic level. Although rs10864294 was significantly associated with the probing depth periodontitis indicators, no candidate SNP was associated with heart disease score so it is not possible to conclude that any of these candidate SNPs explain the significant relationship seen between periodontitis and cardiovascular disease indicators.


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Details

Item Type: University of Pittsburgh ETD
Status: Unpublished
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Verbiar, Julia L.jlv38@pitt.eduJLV38
ETD Committee:
TitleMemberEmail AddressPitt UsernameORCID
Committee ChairShaffer, John R.john.r.shaffer@pitt.edu
Committee MemberDurst, Andrea L.adurst@pitt.edu
Committee MemberNeiswanger, Katherineknacct@pitt.edu
Date: 28 June 2018
Date Type: Publication
Defense Date: 27 March 2018
Approval Date: 28 June 2018
Submission Date: 4 April 2018
Access Restriction: No restriction; Release the ETD for access worldwide immediately.
Number of Pages: 74
Institution: University of Pittsburgh
Schools and Programs: Graduate School of Public Health > Genetic Counseling
Degree: MS - Master of Science
Thesis Type: Master's Thesis
Refereed: Yes
Uncontrolled Keywords: periodontitis, cardiovascular disease, genetics
Date Deposited: 28 Jun 2018 20:15
Last Modified: 28 Jun 2018 20:15
URI: http://d-scholarship.pitt.edu/id/eprint/34061

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