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Studies on the rejection of the transplanted homologous dog liver.

STARZL, TE and KAUPP, HA and BROCK, DR and LINMAN, JW (1961) Studies on the rejection of the transplanted homologous dog liver. Surgery, gynecology & obstetrics, 112. 135 - 144. ISSN 0039-6087

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Abstract

Dogs in which livers have been replaced with hepatic homografts usually die in 5 to 10 days. Liver metabolism is not detectably abnormal at first, but gradual deterioration of function commences on the fourth or fifth day. There was histologic evidence of rejection in all dogs dying after 4 days. This ranged from minimal mononuclear infiltration to almost complete destruction of parenchyma. In the longest survivor, 20 1/2 days, histologic changes were less profound than in many animals dying earlier. Widespread histologic changes were found in host reticuloendothelial system, involving the bone marrow, kidneys, lungs, lymph nodes, and other tissues. These consisted of fixed tissue proliferation and infiltration of mononuclear cells, principally plasma cells. These changes were thought to be due to a general host reticuloendothelial response to the antigenic stimulus of the homograft.


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
STARZL, TEtes11@pitt.eduTES11
KAUPP, HA
BROCK, DR
LINMAN, JW
Centers: Other Centers, Institutes, or Units > Thomas E. Starzl Transplantation Institute
Date: 1 February 1961
Date Type: Publication
Journal or Publication Title: Surgery, gynecology & obstetrics
Volume: 112
Page Range: 135 - 144
Institution: University of Pittsburgh
Refereed: Yes
ISSN: 0039-6087
Other ID: uls-drl:31735062122860, Starzl CV No. 28
Date Deposited: 08 Apr 2010 16:59
Last Modified: 02 Feb 2019 13:55
URI: http://d-scholarship.pitt.edu/id/eprint/3414

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