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A multiple catheter technique for studies or hepatic metabolism and blood flow in dogs with portacaval transposition

Starzl, TE and Lazarus, RE and Schlachter, L and Thornton, FH and Wendel, RM and Stearn, B and Scanlon, WA (1962) A multiple catheter technique for studies or hepatic metabolism and blood flow in dogs with portacaval transposition. Surgery, 52 (4). 654 - 659. ISSN 0039-6060

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Abstract

A technique is described for in vivo hepatic metabolic studies, employing a multiple catheterization technique in dogs with chronic portacaval transposition. The animals are studied in the unanesthetized state immediately after the insertion of catheters through peripheral cut-downs. The gradient of metabolites entering and leaving the liver can be measured concomitantly with hepatic plasma flow. Additional simultaneous gradients can be obtained across the splanchnic capillary bed, or the hindquarters. Drugs can be introduced into the circulation by a systemic route or by primary injection into the hepatic circulation. The advantages of this approach compared to other methods of evaluating moment to moment hepatic function are discussed. © 1962.


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Starzl, TEtes11@pitt.eduTES11
Lazarus, RE
Schlachter, L
Thornton, FH
Wendel, RM
Stearn, B
Scanlon, WA
Centers: Other Centers, Institutes, or Units > Thomas E. Starzl Transplantation Institute
Date: 1 October 1962
Date Type: Publication
Journal or Publication Title: Surgery
Volume: 52
Number: 4
Page Range: 654 - 659
Institution: University of Pittsburgh
Refereed: Yes
ISSN: 0039-6060
Other ID: uls-drl:31735062123116, Starzl CV No. 42
Date Deposited: 08 Apr 2010 16:59
Last Modified: 05 Dec 2017 17:01
URI: http://d-scholarship.pitt.edu/id/eprint/3428

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