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Integrative review of the effect of gluten, if any, on gastrointestinal symptoms in non-celiac disease patients

Caplan, Erin (2018) Integrative review of the effect of gluten, if any, on gastrointestinal symptoms in non-celiac disease patients. Master Essay, University of Pittsburgh.

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Objective: To present an integrative review of literature on the effects of gluten on gastrointestinal symptoms in individuals who do not have celiac disease.
Background: Despite a rapid increase in the number of people who identify as “gluten free,” the prevalence of celiac disease has remained roughly the same. Previous literature testing the effect of gluten on gastrointestinal symptoms has not been conclusive.
Public Health Significance: Many people believe that being “gluten free” is healthier, when in fact gluten-free products often contain more fats and sugars and cost more financially. This diet trend poses a risk on the health of our population.
Data Sources: The electronic databases of PubMed and OVID were used to identify studies using the key words “gluten free diet,” “irritable bowl syndrome,” and “non-celiac gluten sensitivity.”
Study Selection: Using exclusion and inclusion criteria 427 articles’ titles and abstracts were scanned for relevance to adhering to a gluten free diet and specifically addresses patients with non-celiac gluten sensitivity. Further review of references produced four articles. Thirteen articles were read in full. Six studies fully met inclusion and exclusion criteria for full in-depth review.
Data Synthesis: Based on their findings, studies were either categorized as concluding no significant effect of gluten or significant effects of gluten on gastrointestinal symptoms.
Conclusions: Substantially larger, multi-center research studies need to be conducted in order to truly understand the impact of gluten, if any, on gastrointestinal symptoms in non-celiac disease individuals. While some of the studies conclude there are significant detrimental effects as a result of consuming gluten, other studies conclude no significant changes in symptoms.


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Item Type: Other Thesis, Dissertation, or Long Paper (Master Essay)
Status: Unpublished
CreatorsEmailPitt UsernameORCID
Caplan, Erineac95@pitt.edueac95
ContributionContributors NameEmailPitt UsernameORCID
Committee ChairPeterson, Jimjimmp@pitt.eduUNSPECIFIEDUNSPECIFIED
Committee MemberTerry, Marthamaterry@pitt.eduUNSPECIFIEDUNSPECIFIED
Date: 26 April 2018
Date Type: Submission
Number of Pages: 35
Institution: University of Pittsburgh
Schools and Programs: School of Public Health > Environmental and Occupational Health
Degree: MPH - Master of Public Health
Thesis Type: Master Essay
Refereed: Yes
Date Deposited: 14 Nov 2018 20:37
Last Modified: 14 Nov 2018 20:37


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