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Renal homografts in patients with major donor-recipient blood group incompatibilities

Starzl, TE and Marchioro, TL and Holmes, JH and Hermann, G and Brittain, RS and Stonington, OH and Talmage, DW and Waddell, WR (1964) Renal homografts in patients with major donor-recipient blood group incompatibilities. Surgery, 55 (2). 195 - 200. ISSN 0039-6060

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Three documented cases of clinical renal transplantation in which the donor and recipient patients had different major blood types have been presented. The relationship of the donor-recipient pairs ranged from that of sister-to-brother to that of totally unrelated patients of different races. The renal homografts were obtained from living donors in 2 cases and from a recently dead cadaver in the third. Renal function was prompt and excellent when living donors were used, and more indolent when a cadaver kidney subjected to a long period of ischemia was employed. Two of the patients have normal renal function after 74 and 49 days. The third patient died with rejection and sepsis 24 days after transplantation. This study demonstrates the feasibility of obtaining both immediate and prolonged renal function despite the presence of major blood group incompatibilities between donor and recipient patients. This knowledge should expand the donor pool, making it possible to transfer renal homografts under much less stringent requirements than has been the case in the past. © 1964.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Starzl, TEtes11@pitt.eduTES11
Marchioro, TL
Holmes, JH
Hermann, G
Brittain, RS
Stonington, OH
Talmage, DW
Waddell, WR
Centers: Other Centers, Institutes, Offices, or Units > Thomas E. Starzl Transplantation Institute
Date: 1 February 1964
Date Type: Publication
Journal or Publication Title: Surgery
Volume: 55
Number: 2
Page Range: 195 - 200
Institution: University of Pittsburgh
Refereed: Yes
ISSN: 0039-6060
Other ID: uls-drl:31735062123207, Starzl CV No. 61
Date Deposited: 08 Apr 2010 17:00
Last Modified: 02 Feb 2019 13:56


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