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The role of hypoxia and metabolism in High Altitude Renal Syndrome

Murali, Anjana (2018) The role of hypoxia and metabolism in High Altitude Renal Syndrome. Undergraduate Thesis, University of Pittsburgh. (Unpublished)

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Abstract

More than 140 million people permanently live in regions of high altitude. Due to the deficiency of atmospheric oxygen, the inhabitants of these high mountains are subject to compromised physiology and High Altitude Renal Syndrome (HARS). Symptoms of HARS include systemic hypertension, microalbuminuria, polycythemia, and hyperuricemia. While it has been reported that low levels of oxygen result in renal malformations during development, including decreased nephron number, glomerular filtration rate (GFR) is preserved in patients with HARS. This study investigated the roles of hypoxia and metabolism as environmental regulators of kidney development and as driving mechanisms of the disease state HARS. High altitude hypoxia (12% O2) exposure during development alone did not introduce any significant pathology, as evidenced by unchanged proximal tubular morphology and tubular bioenergetic expression. However, the high altitude hypoxia did have a subpathological role in exacerbating kidney injury. As seen through cisplatin-induced AKI, kidneys previously exposed to hypoxia had dilated proximal tubules and proteinaceous casts. Moreover these kidneys were physiologically impaired as seen through significantly upregulated toxic levels of BUN and creatinine. Based on the results of the present study, people living in high altitudes may be more susceptible to secondary insults later in life due to hypoxia’s subpathological role in renal disease progression.


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Details

Item Type: University of Pittsburgh ETD
Status: Unpublished
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Murali, Anjanaanm225@pitt.eduanm225
ETD Committee:
TitleMemberEmail AddressPitt UsernameORCID
Thesis AdvisorSims-Lucas, Sundersunder.sims-lucas@chp.edu
Committee MemberSiegel, Michaelsiegel@pitt.edusiegel
Committee MemberAlter, Josephjsalter@pitt.edujsalter
Committee MemberKapitsinou, Pinelopipkapitsinou@kumc.edu
Date: 3 May 2018
Date Type: Publication
Defense Date: 13 April 2018
Approval Date: 3 May 2018
Submission Date: 2 May 2018
Access Restriction: No restriction; Release the ETD for access worldwide immediately.
Number of Pages: 64
Institution: University of Pittsburgh
Schools and Programs: University Honors College
Dietrich School of Arts and Sciences > Anthropology
Degree: BPhil - Bachelor of Philosophy
Thesis Type: Undergraduate Thesis
Refereed: Yes
Uncontrolled Keywords: kidney development, nephrology, cisplatin-induced acute kidney injury, high altitude renal syndrome, hypoxia
Date Deposited: 03 May 2018 15:56
Last Modified: 03 May 2018 15:56
URI: http://d-scholarship.pitt.edu/id/eprint/34476

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