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Splenectomy and Thymectomy in Human Renal Homotransplantation

Starzl, TE and Marchioro, TL and Talmage, DW and Waddell, WR (1963) Splenectomy and Thymectomy in Human Renal Homotransplantation. Proceedings of the Society for Experimental Biology and Medicine, 113 (4). 929 - 932. ISSN 0037-9727

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Abstract

Five patients with terminal renal failure have been treated with renal homografts. Total body irradiation and cytotoxic drugs were used to prevent rejection. In addition, the thymus and spleen were surgically removed prior to the homotransplantation. Four of the 5 patients are alive with good renal function after 105 to 198 days. The role of thymectomy and splenectomy in conditioning patients for the receipt of homografts is highly speculative at present. However, the early success rate in this group of patients exceeds that generally attained with renal homografts, and appears to justify further clinical evaluation of this approach under carefully controlled experimental conditions. The data are insufficient to allow a recommendation for the general use of these adjuvant procedures. © 1963, SAGE Publications. All rights reserved.


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Starzl, TEtes11@pitt.eduTES11
Marchioro, TL
Talmage, DW
Waddell, WR
Centers: Other Centers, Institutes, or Units > Thomas E. Starzl Transplantation Institute
Date: 1 January 1963
Date Type: Publication
Journal or Publication Title: Proceedings of the Society for Experimental Biology and Medicine
Volume: 113
Number: 4
Page Range: 929 - 932
DOI or Unique Handle: 10.3181/00379727-113-28534
Institution: University of Pittsburgh
Refereed: Yes
ISSN: 0037-9727
Other ID: uls-drl:31735062123249, Starzl CV No. 62
Date Deposited: 08 Apr 2010 17:00
Last Modified: 30 Oct 2017 23:57
URI: http://d-scholarship.pitt.edu/id/eprint/3448

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