Link to the University of Pittsburgh Homepage
Link to the University Library System Homepage Link to the Contact Us Form

The role of adrenocortical steroids in reversing established homograft rejection

Marchioro, TL and Axtell, HK and LaVia, MF and Waddell, WR and Starzl, TE (1964) The role of adrenocortical steroids in reversing established homograft rejection. Surgery, 55 (3). 412 - 417. ISSN 0039-6060

[img]
Preview
PDF
Accepted Version
Available under License : See the attached license file.

Download (812kB) | Preview
[img] Plain Text (licence)
Available under License : See the attached license file.

Download (1kB)

Abstract

Renal homotransplantation was performed in 8 dogs. Antirejection therapy with azathioprine (BW 57-322, Imuran) was given in doses of 2 to 7.5 mg. per kilogram per day. Evidence of rejection developed in all animals from 4 to 32 days following transplantation. When rejection had been established by at least 2 successive elevations of the BUN level, intramuscular injections of prednisolone (50 to 200 mg. per day) were added to the preexisting azathioprine therapy. Seven of the 8 animals had a favorable response evidenced by a falling BUN level, increased urine volumes, and decreasing proteinuria. Gastrointestinal bleeding was a serious complication in 6 of the 8 dogs. It was a direct or contributing cause of death in all 6. The rationale for the use of prednisolone in homotransplantation is discussed. From these experiments it would appear to be a valuable adjunct in reversing established rejection when added in large doses to preexisting antirejection therapy with azathioprine. Vigorous antacid therapy is indicated to prevent gastrointestinal ulceration and bleeding. © 1964.


Share

Citation/Export:
Social Networking:
Share |

Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Marchioro, TL
Axtell, HK
LaVia, MF
Waddell, WR
Starzl, TEtes11@pitt.eduTES11
Centers: Other Centers, Institutes, or Units > Thomas E. Starzl Transplantation Institute
Date: 1 March 1964
Date Type: Publication
Journal or Publication Title: Surgery
Volume: 55
Number: 3
Page Range: 412 - 417
Institution: University of Pittsburgh
Refereed: Yes
ISSN: 0039-6060
Other ID: uls-drl:31735062123827, Starzl CV No. 66
Date Deposited: 08 Apr 2010 17:00
Last Modified: 02 Feb 2019 13:56
URI: http://d-scholarship.pitt.edu/id/eprint/3452

Metrics

Monthly Views for the past 3 years

Plum Analytics


Actions (login required)

View Item View Item