The influence of genotype and perioral musculature on maxillary and mandibular developmentHansen, Sarah E. (2018) The influence of genotype and perioral musculature on maxillary and mandibular development. Master's Thesis, University of Pittsburgh. (Unpublished)
AbstractGrowth and development of the maxilla and mandible are important in diagnosing and treatment planning orthodontic cases. This study reports significant influences on jaw position in 42 adult patients of the University of Pittsburgh School of Dental Medicine. OBJECTIVE: of the study was to determine whether there is an association between skeletal jaw position and perioral musculature, and if genotype can predict skeletal growth. METHODS: a prospective study on 42 patients over one year was performed. Protocols were followed to ensure HIPAA compliance. The average age of subjects was 28.5 years and included 22 females and 20 males. Lip strength measured by the IOPI system was compared to radiographic cephalometric measurements. Allelic and genotypic frequencies from polymorphisms rs678397 and rs1815739 of gene ACTN3, and rs10850110 of gene MYO1H, were compared to each variable. Chi-square and Fisher exact calculations determined significance of associations. RESULTS: showed significant differences between rs10850110 genotype and Steiner classification (P = 0.04); between rs678397 genotype and allele frequency and SNA angle (P = 0.01; P = 0.003); between rs1815739 allele frequency and SNA angle (P = 0.01); between rs678397 allele frequency and ANB angle (P = 0.049); between rs678397 genotype and allele frequency and lip strength in females (P = 0.045; P = 0.02); and between rs678397 allele frequency and overall lip strength (P = 0.049), after being corrected for sex. CONCLUSIONS: The genotype for rs10850110 is associated with a Class III skeletal relationship, and the genotype for polymorphisms rs678397 and rs1815739 are associated with both weak lips and a skeletal Class II phenotype, due to a a protrusive maxilla. Share
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