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Infectious Diseases Associated With Renal Homotransplantation: I. Incidence, Types, and Predisposing Factors

Rifkind, D and Marchioro, TL and Waddell, WR and Starzl, TE (1964) Infectious Diseases Associated With Renal Homotransplantation: I. Incidence, Types, and Predisposing Factors. JAMA: The Journal of the American Medical Association, 189 (6). 397 - 401. ISSN 0098-7484

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Abstract

Infectious diseases occurred in 26 of 30 renal homotransplantation patients and contributed to eight of the 12 deaths in this series. There were 52 infections, 17 occurring before and 35 after transplantation. Infections were produced primarily by staphylococci, Pseudomonas species, and the enteric gram-negative bacilli. Staphylococcal infections occurred in 17 of 19 carriers of this organism and in only one of 11 noncarriers. Thirty-three of the 35 postoperative infections followed the intensification of immunosuppressive therapy for treatment of attempted homograft rejection. Granulocytopenia, steroid-induced diabetes, and hypogammaglobulinemia, from suppressive drug therapy, routinely preceded the onset of these complications. The infections, largely of endogenous origin, occurred when the host's defense mechanisms were depressed. © 1964, American Medical Association. All rights reserved.


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Rifkind, D
Marchioro, TL
Waddell, WR
Starzl, TEtes11@pitt.eduTES11
Centers: Other Centers, Institutes, Offices, or Units > Thomas E. Starzl Transplantation Institute
Date: 10 August 1964
Date Type: Publication
Journal or Publication Title: JAMA: The Journal of the American Medical Association
Volume: 189
Number: 6
Page Range: 397 - 401
DOI or Unique Handle: 10.1001/jama.1964.03070060007001
Institution: University of Pittsburgh
Refereed: Yes
ISSN: 0098-7484
Other ID: uls-drl:31735062122803, Starzl CV No. 78
Date Deposited: 08 Apr 2010 17:00
Last Modified: 09 Dec 2017 12:55
URI: http://d-scholarship.pitt.edu/id/eprint/3464

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