Link to the University of Pittsburgh Homepage
Link to the University Library System Homepage Link to the Contact Us Form

Peripheral Eosinophilia in Patients With Inflammatory Bowel Disease Defines an Aggressive Disease Phenotype

Click, Benjamin and Anderson, Alyce M and Koutroubakis, Ioannis E and Rivers, Claudia Ramos and Babichenko, Dmitriy and Machicado, Jorge D and Hartman, Douglas J and Hashash, Jana G and Dunn, Michael A and Schwartz, Marc (2017) Peripheral Eosinophilia in Patients With Inflammatory Bowel Disease Defines an Aggressive Disease Phenotype. The American journal of gastroenterology, 112 (12). p. 1849.


Peripheral blood eosinophilia (PBE) in inflammatory bowel disease (IBD) is associated with ulcerative colitis (UC) and active disease. Little data exist on the long-term impact of PBE on disease course. We aimed to investigate the multi-year patterns of PBE and its impact on disease severity in a large IBD cohort.

We performed a registry analysis of a consented, prospective, natural history IBD cohort at a tertiary center from 2009 to 2014. Demographics, comorbidities, disease activity, healthcare utilization, and time to hospitalization or surgical resection of patients who displayed PBE were compared to patients without PBE.

Of the 2,066 IBD patients, 19.2% developed PBE. PBE was significantly associated with UC (P<0.001), extensive colitis (P<0.001), and shorter disease duration (P=0.03). Over six years, PBE patients had more active disease (Harvey-Bradshaw Index P=0.001; ulcerative colitis activity index P<0.001), concurrent C-reactive protein elevation (P<0.001), healthcare utilization (hospitalization P<0.001, IBD surgery P<0.001), and more aggressive medical therapy (prednisone P<0.001, anti-TNF P<0.001). Patients with PBE had a significantly reduced time to hospitalization in both UC (P<0.001) and Crohn's disease (CD) (P<0.001) and reduced time to colectomy in UC (P=0.003). On multivariable modeling, PBE remained significantly associated with hospitalization and surgery in both CD and UC. New diagnosis of UC with PBE was associated with increased steroid (P=0.007) and anti-TNF (P=0.001) requirement.

This multi-year study of a large IBD cohort suggests that peripheral blood eosinophilia represents a biomarker of a distinct IBD subgroup, with a unique inflammatory signature, and at risk for worse clinical outcomes.


Social Networking:
Share |


Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Click, Benjamin
Anderson, Alyce M
Koutroubakis, Ioannis E
Rivers, Claudia Ramos
Babichenko, Dmitriydmb72@pitt.edudmb72
Machicado, Jorge D
Hartman, Douglas J
Hashash, Jana G
Dunn, Michael A
Schwartz, Marc
Date: 7 November 2017
Date Type: Publication
Journal or Publication Title: The American journal of gastroenterology
Volume: 112
Number: 12
Publisher: Nature Publishing Group
Page Range: p. 1849
DOI or Unique Handle: 10.1038/ajg.2017.402
Schools and Programs: School of Computing and Information > Information Science
Refereed: Yes
Official URL:
Article Type: Research Article
PubMed ID: 29112200
Date Deposited: 06 Jul 2018 15:36
Last Modified: 28 Jan 2021 20:24


Monthly Views for the past 3 years

Plum Analytics

Actions (login required)

View Item View Item